Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry

Greg A. Snyder; Daniel Deredge; Anna Waldhuber; Theresa Fresquez; David Z. Wilkins; Patrick T. Smith; Susi Durr; Christine Cirl; Jiansheng Jiang; William Jennings; Timothy Luchetti; Nathaniel Snyder; Eric J. Sundberg; Patrick Wintrode; Thomas Miethke; T. Sam Xiao

doi:10.1074/jbc.M113.523407

Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry

Greg A. Snyder
, Daniel Deredge
, Anna Waldhuber
, Theresa Fresquez
, David Z. Wilkins
, Patrick T. Smith
, Susi Durr
, Christine Cirl
, Jiansheng Jiang
, William Jennings
, Timothy Luchetti
, Nathaniel Snyder
, Eric J. Sundberg
, Patrick Wintrode
, Thomas Miethke
, T. Sam Xiao

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Background: The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Results: The crystal structures of the TIR domains from TcpB and TIRAP reveal similar folds and distinct features. Conclusion: TcpB may mimic the function of TIRAP through their similar TIR domain structures.

Original language	English
Pages (from-to)	669-679
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	2
DOIs	https://doi.org/10.1074/jbc.M113.523407
State	Published - Jan 10 2014

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Snyder, G. A., Deredge, D., Waldhuber, A., Fresquez, T., Wilkins, D. Z., Smith, P. T., Durr, S., Cirl, C., Jiang, J., Jennings, W., Luchetti, T., Snyder, N., Sundberg, E. J., Wintrode, P., Miethke, T., & Xiao, T. S. (2014). Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. Journal of Biological Chemistry, 289(2), 669-679. https://doi.org/10.1074/jbc.M113.523407

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title = "Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry",

abstract = "Background: The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Results: The crystal structures of the TIR domains from TcpB and TIRAP reveal similar folds and distinct features. Conclusion: TcpB may mimic the function of TIRAP through their similar TIR domain structures.",

author = "Snyder, \{Greg A.\} and Daniel Deredge and Anna Waldhuber and Theresa Fresquez and Wilkins, \{David Z.\} and Smith, \{Patrick T.\} and Susi Durr and Christine Cirl and Jiansheng Jiang and William Jennings and Timothy Luchetti and Nathaniel Snyder and Sundberg, \{Eric J.\} and Patrick Wintrode and Thomas Miethke and Xiao, \{T. Sam\}",

year = "2014",

month = jan,

day = "10",

doi = "10.1074/jbc.M113.523407",

language = "English",

volume = "289",

pages = "669--679",

journal = "Journal of Biological Chemistry",

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Snyder, GA, Deredge, D, Waldhuber, A, Fresquez, T, Wilkins, DZ, Smith, PT, Durr, S, Cirl, C, Jiang, J, Jennings, W, Luchetti, T, Snyder, N, Sundberg, EJ, Wintrode, P, Miethke, T & Xiao, TS 2014, 'Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry', Journal of Biological Chemistry, vol. 289, no. 2, pp. 669-679. https://doi.org/10.1074/jbc.M113.523407

TY - JOUR

T1 - Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry

AU - Snyder, Greg A.

AU - Deredge, Daniel

AU - Waldhuber, Anna

AU - Fresquez, Theresa

AU - Wilkins, David Z.

AU - Smith, Patrick T.

AU - Durr, Susi

AU - Cirl, Christine

AU - Jiang, Jiansheng

AU - Jennings, William

AU - Luchetti, Timothy

AU - Snyder, Nathaniel

AU - Sundberg, Eric J.

AU - Wintrode, Patrick

AU - Miethke, Thomas

AU - Xiao, T. Sam

PY - 2014/1/10

Y1 - 2014/1/10

N2 - Background: The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Results: The crystal structures of the TIR domains from TcpB and TIRAP reveal similar folds and distinct features. Conclusion: TcpB may mimic the function of TIRAP through their similar TIR domain structures.

AB - Background: The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Results: The crystal structures of the TIR domains from TcpB and TIRAP reveal similar folds and distinct features. Conclusion: TcpB may mimic the function of TIRAP through their similar TIR domain structures.

UR - https://www.scopus.com/pages/publications/84891942344

U2 - 10.1074/jbc.M113.523407

DO - 10.1074/jbc.M113.523407

M3 - Article

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AN - SCOPUS:84891942344

SN - 0021-9258

VL - 289

SP - 669

EP - 679

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 2

ER -

Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry

Abstract

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