Crystal structures of the Toll/Interleukin-1 Receptor (TIR) domains from the brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry

Greg A. Snyder, Daniel Deredge, Anna Waldhuber, Theresa Fresquez, David Z. Wilkins, Patrick T. Smith, Susi Durr, Christine Cirl, Jiansheng Jiang, William Jennings, Timothy Luchetti, Nathaniel Snyder, Eric J. Sundberg, Patrick Wintrode, Thomas Miethke, T. Sam Xiao

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Background: The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Results: The crystal structures of the TIR domains from TcpB and TIRAP reveal similar folds and distinct features. Conclusion: TcpB may mimic the function of TIRAP through their similar TIR domain structures.

Original languageEnglish
Pages (from-to)669-679
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number2
DOIs
StatePublished - Jan 10 2014

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