COX2-dependent suppression of anticancer immunity

María Cecilia Lira; Lorenzo Galluzzi; Claire Vanpouille-Box

doi:10.1016/j.trecan.2024.05.006

COX2-dependent suppression of anticancer immunity

María Cecilia Lira, Lorenzo Galluzzi, Claire Vanpouille-Box

Cornell University

Research output: Contribution to journal › Article › peer-review

Abstract

Prostaglandin E₂ (PGE₂) is well known to promote tumor progression by boosting cancer cell proliferation while inhibiting anticancer immunity. Recent data from Lacher et al. and Morotti et al. demonstrate that one of the mechanisms through which PGE₂ suppresses tumor-targeting immune responses involves downregulation of interleukin 2 (IL2) receptors and consequent inhibition of mitochondrial metabolism in T cells.

Original language	English
Pages (from-to)	573-575
Number of pages	3
Journal	Trends in Cancer
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/j.trecan.2024.05.006
State	Published - Jul 2024
Externally published	Yes

Keywords

apoptosis
CASP3
NK cells
PTGER2
radiation therapy
tumor-infiltrating lymphocyte
Receptors, Interleukin-2/metabolism
Cyclooxygenase 2/metabolism
Mitochondria/metabolism
T-Lymphocytes/immunology
Humans
Animals
Neoplasms/immunology
Dinoprostone/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trecan.2024.05.006

Cite this

@article{1351be54a17143a5b33309e18f0e68b8,

title = "COX2-dependent suppression of anticancer immunity",

abstract = "Prostaglandin E2 (PGE2) is well known to promote tumor progression by boosting cancer cell proliferation while inhibiting anticancer immunity. Recent data from Lacher et al. and Morotti et al. demonstrate that one of the mechanisms through which PGE2 suppresses tumor-targeting immune responses involves downregulation of interleukin 2 (IL2) receptors and consequent inhibition of mitochondrial metabolism in T cells.",

keywords = "apoptosis, CASP3, NK cells, PTGER2, radiation therapy, tumor-infiltrating lymphocyte, Receptors, Interleukin-2/metabolism, Cyclooxygenase 2/metabolism, Mitochondria/metabolism, T-Lymphocytes/immunology, Humans, Animals, Neoplasms/immunology, Dinoprostone/metabolism",

author = "Lira, {Mar{\'i}a Cecilia} and Lorenzo Galluzzi and Claire Vanpouille-Box",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

month = jul,

doi = "10.1016/j.trecan.2024.05.006",

language = "English",

volume = "10",

pages = "573--575",

journal = "Trends in Cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "7",

}

TY - JOUR

T1 - COX2-dependent suppression of anticancer immunity

AU - Lira, María Cecilia

AU - Galluzzi, Lorenzo

AU - Vanpouille-Box, Claire

PY - 2024/7

Y1 - 2024/7

N2 - Prostaglandin E2 (PGE2) is well known to promote tumor progression by boosting cancer cell proliferation while inhibiting anticancer immunity. Recent data from Lacher et al. and Morotti et al. demonstrate that one of the mechanisms through which PGE2 suppresses tumor-targeting immune responses involves downregulation of interleukin 2 (IL2) receptors and consequent inhibition of mitochondrial metabolism in T cells.

AB - Prostaglandin E2 (PGE2) is well known to promote tumor progression by boosting cancer cell proliferation while inhibiting anticancer immunity. Recent data from Lacher et al. and Morotti et al. demonstrate that one of the mechanisms through which PGE2 suppresses tumor-targeting immune responses involves downregulation of interleukin 2 (IL2) receptors and consequent inhibition of mitochondrial metabolism in T cells.

KW - apoptosis

KW - CASP3

KW - NK cells

KW - PTGER2

KW - radiation therapy

KW - tumor-infiltrating lymphocyte

KW - Receptors, Interleukin-2/metabolism

KW - Cyclooxygenase 2/metabolism

KW - Mitochondria/metabolism

KW - T-Lymphocytes/immunology

KW - Humans

KW - Animals

KW - Neoplasms/immunology

KW - Dinoprostone/metabolism

UR - http://www.scopus.com/inward/record.url?scp=85194740976&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2024.05.006

DO - 10.1016/j.trecan.2024.05.006

M3 - Article

C2 - 38821853

AN - SCOPUS:85194740976

SN - 2405-8033

VL - 10

SP - 573

EP - 575

JO - Trends in Cancer

JF - Trends in Cancer

IS - 7

ER -

COX2-dependent suppression of anticancer immunity

Abstract

Keywords

UN SDGs

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