TY - JOUR
T1 - Correlation of flow cytometry to clinical factors, hormone receptors, and histopathological grade in stage I and II invasive breast carcinoma
AU - Haghbin, Mahroo
AU - McCue, Peter A.
AU - Mansfield, Carl M.
AU - Komarnicky, Lydia T.
AU - Benammar, Alia
AU - Schwartz, Gordon F.
PY - 1996/2
Y1 - 1996/2
N2 - DNA index (ploidy) and S-phase fraction (SPF) were measured by flow cytometry in 131 invasive stage I and II breast carcinomas. Ploidy showed a strong correlation with SPF (p = 0.0001), with aneuploid tumors having a high SPF. Both cytometric parameters correlated with tumor size and hormonal receptor status. Smaller tumors tended to be diploid and have low SPF. Nodal status did not demonstrate an association with cytometric findings. There was a highly significant connection between tumor grade, especially nuclear grade, and SPF (p = 0.0001). The study demonstrates the relationship between conventional prognostic factors, DNA content, and proliferative activity of breast tumors.
AB - DNA index (ploidy) and S-phase fraction (SPF) were measured by flow cytometry in 131 invasive stage I and II breast carcinomas. Ploidy showed a strong correlation with SPF (p = 0.0001), with aneuploid tumors having a high SPF. Both cytometric parameters correlated with tumor size and hormonal receptor status. Smaller tumors tended to be diploid and have low SPF. Nodal status did not demonstrate an association with cytometric findings. There was a highly significant connection between tumor grade, especially nuclear grade, and SPF (p = 0.0001). The study demonstrates the relationship between conventional prognostic factors, DNA content, and proliferative activity of breast tumors.
KW - Breast Neoplasms/chemistry
KW - DNA, Neoplasm/analysis
KW - Female
KW - Flow Cytometry
KW - Humans
KW - Neoplasm Invasiveness
KW - Neoplasm Staging
KW - Ploidies
KW - Prognosis
KW - Receptors, Estrogen/analysis
KW - Receptors, Progesterone/analysis
KW - S Phase
UR - http://www.scopus.com/inward/record.url?scp=0030060289&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1996TR33900012&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1097/00000421-199602000-00012
DO - 10.1097/00000421-199602000-00012
M3 - Article
C2 - 8554037
SN - 0277-3732
VL - 19
SP - 54
EP - 58
JO - American Journal of Clinical Oncology: Cancer Clinical Trials
JF - American Journal of Clinical Oncology: Cancer Clinical Trials
IS - 1
ER -
