Control of STIM and Orai function by post-translational modifications

Jinsy Johnson; Rachel Blackman; Scott Gross; Jonathan Soboloff

doi:10.1016/j.ceca.2022.102544

Control of STIM and Orai function by post-translational modifications

Jinsy Johnson
, Rachel Blackman
, Scott Gross
, Jonathan Soboloff

Temple University

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca²⁺ sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai (Orai1, Orai2, Orai3) Ca²⁺ channels. Although primarily regulated by ER Ca²⁺ content, there have been numerous studies over the last 15 years demonstrating that all 5 proteins are also regulated through post-translational modification (PTM). Focusing primarily on phosphorylation, glycosylation and redox modification, this review focuses on how PTMs modulate the key events in SOCE; Ca²⁺ sensing, STIM translocation, Orai interaction and/or Orai1 activation.

Original language	English
Article number	102544
Journal	Cell Calcium
Volume	103
DOIs	https://doi.org/10.1016/j.ceca.2022.102544
State	Published - May 2022

Keywords

Calcium
Glycosylation
Nitrosylation
Orai1
Oxidation
Phosphorylation
Post-translational modification
STIM1
Oxidation-Reduction
Stromal Interaction Molecule 1/metabolism
ORAI1 Protein/metabolism
Calcium/metabolism
Calcium Signaling/physiology
Cell Membrane/metabolism
Protein Processing, Post-Translational
Endoplasmic Reticulum/metabolism

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10.1016/j.ceca.2022.102544

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@article{4966b561ee5143d287134688e4608269,

title = "Control of STIM and Orai function by post-translational modifications",

abstract = "Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai (Orai1, Orai2, Orai3) Ca2+ channels. Although primarily regulated by ER Ca2+ content, there have been numerous studies over the last 15 years demonstrating that all 5 proteins are also regulated through post-translational modification (PTM). Focusing primarily on phosphorylation, glycosylation and redox modification, this review focuses on how PTMs modulate the key events in SOCE; Ca2+ sensing, STIM translocation, Orai interaction and/or Orai1 activation.",

keywords = "Calcium, Glycosylation, Nitrosylation, Orai1, Oxidation, Phosphorylation, Post-translational modification, STIM1, Oxidation-Reduction, Stromal Interaction Molecule 1/metabolism, ORAI1 Protein/metabolism, Calcium/metabolism, Calcium Signaling/physiology, Cell Membrane/metabolism, Protein Processing, Post-Translational, Endoplasmic Reticulum/metabolism",

author = "Jinsy Johnson and Rachel Blackman and Scott Gross and Jonathan Soboloff",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = may,

doi = "10.1016/j.ceca.2022.102544",

language = "English",

volume = "103",

journal = "Cell Calcium",

issn = "0143-4160",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Control of STIM and Orai function by post-translational modifications

AU - Johnson, Jinsy

AU - Blackman, Rachel

AU - Gross, Scott

AU - Soboloff, Jonathan

PY - 2022/5

Y1 - 2022/5

N2 - Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai (Orai1, Orai2, Orai3) Ca2+ channels. Although primarily regulated by ER Ca2+ content, there have been numerous studies over the last 15 years demonstrating that all 5 proteins are also regulated through post-translational modification (PTM). Focusing primarily on phosphorylation, glycosylation and redox modification, this review focuses on how PTMs modulate the key events in SOCE; Ca2+ sensing, STIM translocation, Orai interaction and/or Orai1 activation.

AB - Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai (Orai1, Orai2, Orai3) Ca2+ channels. Although primarily regulated by ER Ca2+ content, there have been numerous studies over the last 15 years demonstrating that all 5 proteins are also regulated through post-translational modification (PTM). Focusing primarily on phosphorylation, glycosylation and redox modification, this review focuses on how PTMs modulate the key events in SOCE; Ca2+ sensing, STIM translocation, Orai interaction and/or Orai1 activation.

KW - Calcium

KW - Glycosylation

KW - Nitrosylation

KW - Orai1

KW - Oxidation

KW - Phosphorylation

KW - Post-translational modification

KW - STIM1

KW - Oxidation-Reduction

KW - Stromal Interaction Molecule 1/metabolism

KW - ORAI1 Protein/metabolism

KW - Calcium/metabolism

KW - Calcium Signaling/physiology

KW - Cell Membrane/metabolism

KW - Protein Processing, Post-Translational

KW - Endoplasmic Reticulum/metabolism

UR - https://www.scopus.com/pages/publications/85124241594

U2 - 10.1016/j.ceca.2022.102544

DO - 10.1016/j.ceca.2022.102544

M3 - Review article

C2 - 35151050

SN - 0143-4160

VL - 103

JO - Cell Calcium

JF - Cell Calcium

M1 - 102544

ER -

Control of STIM and Orai function by post-translational modifications

Abstract

Keywords

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