Control of host mitochondria by bacterial pathogens

Saverio Marchi; Gianluca Morroni; Paolo Pinton; Lorenzo Galluzzi

doi:10.1016/j.tim.2021.09.010

Control of host mitochondria by bacterial pathogens

Saverio Marchi, Gianluca Morroni, Paolo Pinton, Lorenzo Galluzzi

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca²⁺ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.

Original language	English
Pages (from-to)	452-465
Number of pages	14
Journal	Trends in Microbiology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/j.tim.2021.09.010
State	Published - May 2022
Externally published	Yes

Keywords

autophagy
Listeria monocytogenes
mitochondria-associated ER membranes
Mycobacterium tuberculosis
oxidative phosphorylation
regulated cell death
Mitochondria
Energy Metabolism
Homeostasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2021.09.010

Cite this

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title = "Control of host mitochondria by bacterial pathogens",

abstract = "Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.",

keywords = "autophagy, Listeria monocytogenes, mitochondria-associated ER membranes, Mycobacterium tuberculosis, oxidative phosphorylation, regulated cell death, Mitochondria, Energy Metabolism, Homeostasis",

author = "Saverio Marchi and Gianluca Morroni and Paolo Pinton and Lorenzo Galluzzi",

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year = "2022",

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doi = "10.1016/j.tim.2021.09.010",

language = "English",

volume = "30",

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TY - JOUR

T1 - Control of host mitochondria by bacterial pathogens

AU - Marchi, Saverio

AU - Morroni, Gianluca

AU - Pinton, Paolo

AU - Galluzzi, Lorenzo

PY - 2022/5

Y1 - 2022/5

N2 - Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.

AB - Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.

KW - autophagy

KW - Listeria monocytogenes

KW - mitochondria-associated ER membranes

KW - Mycobacterium tuberculosis

KW - oxidative phosphorylation

KW - regulated cell death

KW - Mitochondria

KW - Energy Metabolism

KW - Homeostasis

UR - http://www.scopus.com/inward/record.url?scp=85118165368&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2021.09.010

DO - 10.1016/j.tim.2021.09.010

M3 - Review article

C2 - 34656395

AN - SCOPUS:85118165368

SN - 0966-842X

VL - 30

SP - 452

EP - 465

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 5

ER -

Control of host mitochondria by bacterial pathogens

Abstract

Keywords

UN SDGs

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