Continuous infusion 5-fluorouracil with bolus adriamycin and mitomycin and low-dose cisplatin (FAMP) in the treatment of metastatic gastric carcinoma: An evaluation of efficacy and toxicity

James W. Raschko, Elizabeth A. Johnson, Winston Ueno, Paul V. Woolley, Joseph Treat

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A pilot study was performed to evaluate the feasability of administering prolonged continuous infusion 5-fluorouracil with multiple bolus chemotherapeutic agents. Twelve patients with advanced measurable gastric carcinoma were treated with a combination chemotherapy program of continuous infusion 5-fluorouracil, bolus Adriamycin, mitomycin C, and low-dose cisplatin (FAMP). Responses were observed in 5 patients (2 complete and 3 partial). Observed toxicities included leukopenia, thrombocytopenia, mucositis, and hand-foot syndrome. Although the FAMP regimen has activity in advanced gastric carcinoma, the number of patients evaluated was small and significant improvement over currently available regimens could not be demonstrated. Evaluation of toxicities indicates that bolus administration of multiple agents (specifically, Adriamycin, mitomycin C, and cisplatin) can be used in conjunction with continuously infused 5-fluorouracil without excessive toxicity.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalCancer Investigation
Volume9
Issue number1
DOIs
StatePublished - 1991

Keywords

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols/adverse effects
  • Cisplatin/administration & dosage
  • Doxorubicin/administration & dosage
  • Female
  • Fluorouracil/administration & dosage
  • Humans
  • Infusions, Intravenous
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Mitomycins/administration & dosage
  • Neoplasm Metastasis
  • Pilot Projects
  • Stomach Neoplasms/drug therapy

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