TY - JOUR
T1 - Comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"
AU - Chisari, Francis V.
AU - Mason, William S.
AU - Seeger, Christoph
N1 - Copyright © 2014, American Association for the Advancement of Science.
PY - 2014
Y1 - 2014
N2 - Lucifora et al. (Research Articles, 14 March 2014, p. 1221) report that the hepatitis B virus (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncytolytically by agents that up-regulate APOBEC3A and 3B. If these results can be independently confirmed, they would represent a critical first step toward development of a cure for the 400 million patients who are chronically infected by HBV.
AB - Lucifora et al. (Research Articles, 14 March 2014, p. 1221) report that the hepatitis B virus (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncytolytically by agents that up-regulate APOBEC3A and 3B. If these results can be independently confirmed, they would represent a critical first step toward development of a cure for the 400 million patients who are chronically infected by HBV.
UR - http://www.scopus.com/inward/record.url?scp=84902595106&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000337077500028&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1126/science.1254082
DO - 10.1126/science.1254082
M3 - Comment/debate
C2 - 24926010
SN - 0036-8075
VL - 344
SP - 1237a
JO - Science
JF - Science
IS - 6189
ER -
