TY - JOUR
T1 - Combining Immunotherapy and Chemotherapy for Non-Small Cell Lung Cancer
AU - Judd, Julia
AU - Borghaei, Hossein
N1 - Publisher Copyright:
Copyright © 2020 Elsevier Inc. All rights reserved.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Over the past year, the combination of platinum-based chemotherapy and immunotherapy has become the standard of care for patients with metastatic non-small-cell lung cancer with any programmed death ligand 1 tumor proportion score. There is preclinical evidence demonstrating potential synergistic immunomodulation with combination therapy by enhancing immune-mediated tumor death and by disrupting the immunosuppressive tumor microenvironment that prevents immune detection. This potential synergy or complementary activity has been demonstrated in clinical trials showing improved and durable responses with chemo-immunotherapy.
AB - Over the past year, the combination of platinum-based chemotherapy and immunotherapy has become the standard of care for patients with metastatic non-small-cell lung cancer with any programmed death ligand 1 tumor proportion score. There is preclinical evidence demonstrating potential synergistic immunomodulation with combination therapy by enhancing immune-mediated tumor death and by disrupting the immunosuppressive tumor microenvironment that prevents immune detection. This potential synergy or complementary activity has been demonstrated in clinical trials showing improved and durable responses with chemo-immunotherapy.
KW - Antineoplastic Agents/pharmacology
KW - Carcinoma, Non-Small-Cell Lung/pathology
KW - Combined Modality Therapy
KW - Humans
KW - Immunotherapy/methods
KW - Lung Neoplasms/pathology
KW - Molecular Targeted Therapy/methods
KW - Programmed Cell Death 1 Receptor/antagonists & inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85084030617&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000528218000011&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.thorsurg.2020.01.006
DO - 10.1016/j.thorsurg.2020.01.006
M3 - Review article
C2 - 32327178
SN - 1547-4127
VL - 30
SP - 199
EP - 206
JO - Thoracic Surgery Clinics
JF - Thoracic Surgery Clinics
IS - 2
ER -