Colonic protection from dimethylhydrazine by a high fiber diet

W. F. Chen, A. S. Patchefsky, H. S. Goldsmith

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Results of this experiment showed that a high fiber bran diet had the ability to lower significantly the incidence of pathologic changes in the colon of mice receiving 1,2-dimethylhydrazine, a drug known for its specificity for causing carcinoma of the colon. This finding adds support to the hypothesis which claims that the addition of bran to the diet has the ability to lower the incidence of carcinoma of the large intestine.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalSurgery Gynecology and Obstetrics
Volume147
Issue number4
StatePublished - 1978

Keywords

  • Adenoma/chemically induced
  • Animals
  • Carcinoma in Situ/chemically induced
  • Cellulose/therapeutic use
  • Colonic Neoplasms/chemically induced
  • Dietary Fiber/therapeutic use
  • Dimethylhydrazines/adverse effects
  • Female
  • Methylhydrazines/adverse effects
  • Mice
  • Neoplasms, Experimental/chemically induced

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