Coexisting myelodysplasia and myeloproliferative features in a single clone containing 5q-, Ph and i(17q)

Carlos A. Garay; Tahseen Al-Saleem; Joseph R. Testa; Mitchell R. Smith

doi:10.1016/S0145-2126(99)00115-0

Coexisting myelodysplasia and myeloproliferative features in a single clone containing 5q-, Ph and i(17q)

Carlos A. Garay, Tahseen Al-Saleem, Joseph R. Testa, Mitchell R. Smith

Cancer Prevention and Control (CPC)

Fox Chase Cancer Center

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A case with myelodysplasia in which a single clone contained both 5q- and Ph chromosomes at diagnosis is presented. The patient subsequently developed leukocytosis and at that time was found to have acquired an additional chromosomal abnormality, i(17)(q10). This case illustrates the role of three different genetic changes that impart different clinical characteristics, i.e. myelodysplastic as well as myeloproliferative changes, as part of a multistep leukemogenic process.

Original language	English
Pages (from-to)	965-967
Number of pages	3
Journal	Leukemia Research
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/S0145-2126(99)00115-0
State	Published - Oct 1999

Keywords

Blast crisis
Chromosome 17 abnormalities
Chromosome 5 abnormalities
Chronic myelogenous leukemia
Myelodysplasia
Philadelphia syndrome

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title = "Coexisting myelodysplasia and myeloproliferative features in a single clone containing 5q-, Ph and i(17q)",

abstract = "A case with myelodysplasia in which a single clone contained both 5q- and Ph chromosomes at diagnosis is presented. The patient subsequently developed leukocytosis and at that time was found to have acquired an additional chromosomal abnormality, i(17)(q10). This case illustrates the role of three different genetic changes that impart different clinical characteristics, i.e. myelodysplastic as well as myeloproliferative changes, as part of a multistep leukemogenic process.",

keywords = "Blast crisis, Chromosome 17 abnormalities, Chromosome 5 abnormalities, Chronic myelogenous leukemia, Myelodysplasia, Philadelphia syndrome",

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AU - Al-Saleem, Tahseen

AU - Testa, Joseph R.

AU - Smith, Mitchell R.

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KW - Chromosome 5 abnormalities

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KW - Myelodysplasia

KW - Philadelphia syndrome

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Coexisting myelodysplasia and myeloproliferative features in a single clone containing 5q-, Ph and i(17q)

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