Clinical and Molecular Features of Anti-CENP-B Autoantibodies

Rahul M. Prasad; Alfonso Bellacosa; Tim J. Yen

doi:10.3390/jmp2040024

Clinical and Molecular Features of Anti-CENP-B Autoantibodies

Rahul M. Prasad, Alfonso Bellacosa, Tim J. Yen

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantly CENP-B, and are highly associated with rheumatologic disease (lcSSc/CREST syndrome). CENP-B autoantibodies have also been reported in cancer patients without symptoms of rheumatologic disease. The rise of oncoimmunotherapy stimulates inquiry into how and why anti-CENP-B autoantibodies are formed. In this review, we describe the clinical correlations between anti-CENP-B autoantibodies, rheumatologic disease, and cancer; the molecular features of CENP-B; possible explanations for autoantigenicity; and, finally, a possible mechanism for induction of autoantibody formation.

Original language	English
Pages (from-to)	281-295
Number of pages	15
Journal	Journal of Molecular Pathology
Volume	2
Issue number	4
DOIs	https://doi.org/10.3390/jmp2040024
State	Published - Dec 2021

Keywords

autoimmunity
cancer
CENP-B
centromere
scleroderma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jmp2040024

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title = "Clinical and Molecular Features of Anti-CENP-B Autoantibodies",

abstract = "Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantly CENP-B, and are highly associated with rheumatologic disease (lcSSc/CREST syndrome). CENP-B autoantibodies have also been reported in cancer patients without symptoms of rheumatologic disease. The rise of oncoimmunotherapy stimulates inquiry into how and why anti-CENP-B autoantibodies are formed. In this review, we describe the clinical correlations between anti-CENP-B autoantibodies, rheumatologic disease, and cancer; the molecular features of CENP-B; possible explanations for autoantigenicity; and, finally, a possible mechanism for induction of autoantibody formation.",

keywords = "autoimmunity, cancer, CENP-B, centromere, scleroderma",

author = "Prasad, {Rahul M.} and Alfonso Bellacosa and Yen, {Tim J.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors.",

year = "2021",

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doi = "10.3390/jmp2040024",

language = "English",

volume = "2",

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TY - JOUR

T1 - Clinical and Molecular Features of Anti-CENP-B Autoantibodies

AU - Prasad, Rahul M.

AU - Bellacosa, Alfonso

AU - Yen, Tim J.

PY - 2021/12

Y1 - 2021/12

N2 - Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantly CENP-B, and are highly associated with rheumatologic disease (lcSSc/CREST syndrome). CENP-B autoantibodies have also been reported in cancer patients without symptoms of rheumatologic disease. The rise of oncoimmunotherapy stimulates inquiry into how and why anti-CENP-B autoantibodies are formed. In this review, we describe the clinical correlations between anti-CENP-B autoantibodies, rheumatologic disease, and cancer; the molecular features of CENP-B; possible explanations for autoantigenicity; and, finally, a possible mechanism for induction of autoantibody formation.

AB - Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantly CENP-B, and are highly associated with rheumatologic disease (lcSSc/CREST syndrome). CENP-B autoantibodies have also been reported in cancer patients without symptoms of rheumatologic disease. The rise of oncoimmunotherapy stimulates inquiry into how and why anti-CENP-B autoantibodies are formed. In this review, we describe the clinical correlations between anti-CENP-B autoantibodies, rheumatologic disease, and cancer; the molecular features of CENP-B; possible explanations for autoantigenicity; and, finally, a possible mechanism for induction of autoantibody formation.

KW - autoimmunity

KW - cancer

KW - CENP-B

KW - centromere

KW - scleroderma

UR - http://www.scopus.com/inward/record.url?scp=85141567507&partnerID=8YFLogxK

U2 - 10.3390/jmp2040024

DO - 10.3390/jmp2040024

M3 - Review article

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VL - 2

SP - 281

EP - 295

JO - Journal of Molecular Pathology

JF - Journal of Molecular Pathology

IS - 4

ER -

Clinical and Molecular Features of Anti-CENP-B Autoantibodies

Abstract

Keywords

UN SDGs

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