Cleft lip and palate in family members of cancer survivors

E. Taioli; C. Ragin; L. Robertson; F. Linkov; N. E. Thurman; A. R. Vieira

doi:10.3109/07357907.2010.483510

Cleft lip and palate in family members of cancer survivors

E. Taioli, C. Ragin, L. Robertson, F. Linkov, N. E. Thurman, A. R. Vieira

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75-17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.

Original language	English
Pages (from-to)	958-962
Number of pages	5
Journal	Cancer Investigation
Volume	28
Issue number	9
DOIs	https://doi.org/10.3109/07357907.2010.483510
State	Published - Oct 2010
Externally published	Yes

Keywords

Cancer susceptibility genes
Congenital defects
Family studies

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/07357907.2010.483510

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title = "Cleft lip and palate in family members of cancer survivors",

abstract = "The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75-17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.",

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T1 - Cleft lip and palate in family members of cancer survivors

AU - Taioli, E.

AU - Ragin, C.

AU - Robertson, L.

AU - Linkov, F.

AU - Thurman, N. E.

AU - Vieira, A. R.

PY - 2010/10

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N2 - The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75-17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.

AB - The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75-17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.

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KW - Congenital defects

KW - Family studies

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Cleft lip and palate in family members of cancer survivors

Abstract

Keywords

UN SDGs

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