TY - JOUR
T1 - Circulating tumor cells
T2 - Evolving evidence and future challenges
AU - Dotan, Efrat
AU - Cohen, Steven J.
AU - Alpaugh, Katherine R.
AU - Meropol, Neal J.
PY - 2009
Y1 - 2009
N2 - Circulating tumor cells (CTCs) are rare malignant cells found in the peripheral blood that originate from the primary tumor or metastatic sites. New techniques have been developed to isolate and characterize these cells. CTC enumeration has been incorporated into different fields of oncology as a prognostic marker, a tool to monitor therapy response, and a method to understand basic tumor characteristics. This review covers the different techniques available for isolation of CTCs, the clinical utility of CTCs in breast, prostate, and colon cancer, and future directions in this field.
AB - Circulating tumor cells (CTCs) are rare malignant cells found in the peripheral blood that originate from the primary tumor or metastatic sites. New techniques have been developed to isolate and characterize these cells. CTC enumeration has been incorporated into different fields of oncology as a prognostic marker, a tool to monitor therapy response, and a method to understand basic tumor characteristics. This review covers the different techniques available for isolation of CTCs, the clinical utility of CTCs in breast, prostate, and colon cancer, and future directions in this field.
KW - Breast cancer
KW - Circulating tumor cells
KW - Colon cancer
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=75449084154&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000272166800003&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1634/theoncologist.2009-0094
DO - 10.1634/theoncologist.2009-0094
M3 - Review article
C2 - 19897536
SN - 1083-7159
VL - 14
SP - 1070
EP - 1082
JO - Oncologist
JF - Oncologist
IS - 11
ER -
