Cilia and cilia-associated proteins in cancer

Tamina Seeger-Nukpezah; Joy L Little; Victoria Serzhanova; Erica A Golemis

doi:10.1016/j.ddmec.2013.03.004

Cilia and cilia-associated proteins in cancer

Tamina Seeger-Nukpezah
, Joy L Little
, Victoria Serzhanova
, Erica A Golemis

Fox Chase Cancer Center
Program in Developmental Therapeutics

Research output: Contribution to journal › Article › peer-review

Abstract

The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9, and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma, and breast cancer.

Original language	English
Pages (from-to)	e135-e142
Journal	Drug Discovery Today: Disease Mechanisms
Volume	10
Issue number	3-4
DOIs	https://doi.org/10.1016/j.ddmec.2013.03.004
State	Published - Dec 1 2013

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SDG 3 Good Health and Well-being

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10.1016/j.ddmec.2013.03.004

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title = "Cilia and cilia-associated proteins in cancer",

abstract = "The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9, and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma, and breast cancer.",

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AB - The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9, and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma, and breast cancer.

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JO - Drug Discovery Today: Disease Mechanisms

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ER -

Cilia and cilia-associated proteins in cancer

Abstract

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