Chromosome 16 Rearrangements in Acute Myelomonocytic Leukemia with Abnormal Eosinophils

Joseph R. Testa, Donna E. Hogge, Shinichi Misawa, Nasser Zandparsa, Michelle M. le Beau, Mitchell A. Bitter, Janet D. Rowley

Research output: Contribution to journalLetterpeer-review

47 Scopus citations

Abstract

To the Editor: Recently, a partial deletion of the long arm of chromosome 16, del(16)(q22), was reported in patients with bone-marrow eosinophilia and acute nonlymphocytic leukemia.1 Le Beau et al.2 subsequently identified an apparently related cytogenetic-clinicopathological correlation: an association of a pericentric inversion of chromosome 16, inv(16)(pl3;q22), with abnormal marrow eosinophils in acute myelomonocytic leukemia (acute nonlymphocytic leukemia subtype M4).3 We have identified acquired structural rearrangements of chromosome 16 in bone-marrow cells from four patients with acute nonlymphocytic leukemia. Three of the patients had an inversion of chromosome 16, inv(16)(pl3q22). The fourth patient had a translocation involving both chromosome 16.

Original languageEnglish
Pages (from-to)468-469
Number of pages2
JournalNew England Journal of Medicine
Volume310
Issue number7
DOIs
StatePublished - Feb 16 1984

Keywords

  • Chromosome Aberrations
  • Chromosomes, Human, 16-18
  • Eosinophils/pathology
  • Humans
  • Leukemia, Myeloid, Acute/genetics

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