Chromosomal Localization of the Genes Encoding the Kinetochore Proteins CENPE and CENPF to Human Chromosomes 4q24 → q25 and 1q32 → q41, Respectively, by Fluorescence in Situ Hybridization

Joseph R. Testa; Jian Yuan Zhou; Daphne W. Bell; Tim J. Yen

doi:10.1006/geno.1994.1558

Chromosomal Localization of the Genes Encoding the Kinetochore Proteins CENPE and CENPF to Human Chromosomes 4q24 → q25 and 1q32 → q41, Respectively, by Fluorescence in Situ Hybridization

Joseph R. Testa, Jian Yuan Zhou, Daphne W. Bell, Tim J. Yen

Cancer Prevention and Control (CPC)

Fox Chase Cancer Center

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

CENPE and CENPF are human kinetochore proteins of 312 and ∼400 kDa, respectively. As part of an effort to characterize the functions of these two proteins, we have used their respective cDNAs to map their human chromosomal locations by fluorescence in situ hybridization. The gene that encodes CENPE, a kinetochore-associated motor protein that is postulated to segregate chromosomes during mitosis, maps to chromosome 4q24 → q25. The CENPF gene, which encodes a structural protein of the kinetochore, maps to chromosome 1q32 → q41 within close proximity to the genetic locus that is linked to Van der Woude syndrome.

Original language	English
Pages (from-to)	691-693
Number of pages	3
Journal	Genomics
Volume	23
Issue number	3
DOIs	https://doi.org/10.1006/geno.1994.1558
State	Published - Oct 1994

Keywords

Chromosomal Proteins, Non-Histone/genetics
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 4
DNA Probes
DNA, Complementary
Humans
In Situ Hybridization, Fluorescence
Kinetochores
Restriction Mapping

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10.1006/geno.1994.1558

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title = "Chromosomal Localization of the Genes Encoding the Kinetochore Proteins CENPE and CENPF to Human Chromosomes 4q24 → q25 and 1q32 → q41, Respectively, by Fluorescence in Situ Hybridization",

abstract = "CENPE and CENPF are human kinetochore proteins of 312 and ∼400 kDa, respectively. As part of an effort to characterize the functions of these two proteins, we have used their respective cDNAs to map their human chromosomal locations by fluorescence in situ hybridization. The gene that encodes CENPE, a kinetochore-associated motor protein that is postulated to segregate chromosomes during mitosis, maps to chromosome 4q24 → q25. The CENPF gene, which encodes a structural protein of the kinetochore, maps to chromosome 1q32 → q41 within close proximity to the genetic locus that is linked to Van der Woude syndrome.",

keywords = "Chromosomal Proteins, Non-Histone/genetics, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 4, DNA Probes, DNA, Complementary, Humans, In Situ Hybridization, Fluorescence, Kinetochores, Restriction Mapping",

author = "Testa, {Joseph R.} and Zhou, {Jian Yuan} and Bell, {Daphne W.} and Yen, {Tim J.}",

year = "1994",

month = oct,

doi = "10.1006/geno.1994.1558",

language = "English",

volume = "23",

pages = "691--693",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "3",

}

Chromosomal Localization of the Genes Encoding the Kinetochore Proteins CENPE and CENPF to Human Chromosomes 4q24 → q25 and 1q32 → q41, Respectively, by Fluorescence in Situ Hybridization. / Testa, Joseph R.; Zhou, Jian Yuan; Bell, Daphne W. et al.
In: Genomics, Vol. 23, No. 3, 10.1994, p. 691-693.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Chromosomal Localization of the Genes Encoding the Kinetochore Proteins CENPE and CENPF to Human Chromosomes 4q24 → q25 and 1q32 → q41, Respectively, by Fluorescence in Situ Hybridization

AU - Testa, Joseph R.

AU - Zhou, Jian Yuan

AU - Bell, Daphne W.

AU - Yen, Tim J.

PY - 1994/10

Y1 - 1994/10

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AB - CENPE and CENPF are human kinetochore proteins of 312 and ∼400 kDa, respectively. As part of an effort to characterize the functions of these two proteins, we have used their respective cDNAs to map their human chromosomal locations by fluorescence in situ hybridization. The gene that encodes CENPE, a kinetochore-associated motor protein that is postulated to segregate chromosomes during mitosis, maps to chromosome 4q24 → q25. The CENPF gene, which encodes a structural protein of the kinetochore, maps to chromosome 1q32 → q41 within close proximity to the genetic locus that is linked to Van der Woude syndrome.

KW - Chromosomal Proteins, Non-Histone/genetics

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 1

KW - Chromosomes, Human, Pair 4

KW - DNA Probes

KW - DNA, Complementary

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Kinetochores

KW - Restriction Mapping

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DO - 10.1006/geno.1994.1558

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AN - SCOPUS:0027945510

SN - 0888-7543

VL - 23

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EP - 693

JO - Genomics

JF - Genomics

IS - 3

ER -

Chromosomal Localization of the Genes Encoding the Kinetochore Proteins CENPE and CENPF to Human Chromosomes 4q24 → q25 and 1q32 → q41, Respectively, by Fluorescence in Situ Hybridization

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Keywords

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