Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy

Yuting Ma; Sandy Adjemian; Lorenzo Galluzzi; Laurence Zitvogel; Guido Kroemer

doi:10.4161/onci.27663

Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy

Yuting Ma, Sandy Adjemian, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Depending on tumor type, stage and immunological contexture, the inhibition of chemokines or their receptors may yield positive or deleterious effects on disease progression. We have recently demonstrated in several murine models of anthracycline-based chemotherapy that the inhibition of chemokine (C-C motif) ligand 2 (CCL2) or chemokine (C-C motif) receptor 2 (CCR2) may impair the elicitation of anticancer immune responses that contribute to therapeutic success.

Original language	English
Article number	e27663
Journal	Oncoimmunology
Volume	3
Issue number	1
DOIs	https://doi.org/10.4161/onci.27663
State	Published - 2014
Externally published	Yes

Keywords

ATP
Autophagy
Cancer stem cells
Immunogenic cell death
Immunosurveillance
T lymphocytes
γδ

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.27663

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AU - Adjemian, Sandy

AU - Galluzzi, Lorenzo

AU - Zitvogel, Laurence

AU - Kroemer, Guido

PY - 2014

Y1 - 2014

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AB - Depending on tumor type, stage and immunological contexture, the inhibition of chemokines or their receptors may yield positive or deleterious effects on disease progression. We have recently demonstrated in several murine models of anthracycline-based chemotherapy that the inhibition of chemokine (C-C motif) ligand 2 (CCL2) or chemokine (C-C motif) receptor 2 (CCR2) may impair the elicitation of anticancer immune responses that contribute to therapeutic success.

KW - ATP

KW - Autophagy

KW - Cancer stem cells

KW - Immunogenic cell death

KW - Immunosurveillance

KW - T lymphocytes

KW - γδ

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M3 - Article

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JO - Oncoimmunology

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IS - 1

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ER -

Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy

Abstract

Keywords

UN SDGs

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