Changes of thymocyte subpopulations induced by activities diffusing from leukemia L1210 cells

J. Kawiak; M. Kawalec; G. Hoser; B. Miks; T. Skorski; Z. Pojda; H. Skurzak

Changes of thymocyte subpopulations induced by activities diffusing from leukemia L1210 cells

J. Kawiak, M. Kawalec, G. Hoser, B. Miks, T. Skorski, Z. Pojda, H. Skurzak

Medical Centre for Postgraduate Education, Warsaw

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Mice with intraperitoneally inoculated leukemia L1210 cells had a lower total number of thymocytes and a markedly reduced percentage of L3T4⁺Lyt2⁺ (CD4⁺ 8⁺) thymocytes, but increased subpopulations of L3T4⁺Lyt2^-, L3T4^-Lyt2⁺, L3T4^-Lyt2^-. The percentage of Thy 1.2⁺ thymocytes was unchanged as compared with control animals. A similar effect was observed with leukemia cells (10⁶) enclosed in diffusion chambers and implanted i.p. It is suggested that leukemia L1210 cells produce some activities which diffuse through 0.22 μm filters and influence the subpopulations of thymocytes.

Original language	English
Pages (from-to)	185-192
Number of pages	8
Journal	Thymus
Volume	18
Issue number	3
State	Published - 1991

Keywords

Animals
CD4 Antigens
CD8 Antigens
Cell Differentiation/immunology
Cell Line, Transformed/immunology
Diffusion Chambers, Culture
Leukemia L1210/immunology
Lymphocyte Subsets/immunology
Mice
Thymus Gland/cytology

Cite this

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title = "Changes of thymocyte subpopulations induced by activities diffusing from leukemia L1210 cells",

abstract = "Mice with intraperitoneally inoculated leukemia L1210 cells had a lower total number of thymocytes and a markedly reduced percentage of L3T4+Lyt2+ (CD4+ 8+) thymocytes, but increased subpopulations of L3T4+Lyt2-, L3T4-Lyt2+, L3T4-Lyt2-. The percentage of Thy 1.2+ thymocytes was unchanged as compared with control animals. A similar effect was observed with leukemia cells (106) enclosed in diffusion chambers and implanted i.p. It is suggested that leukemia L1210 cells produce some activities which diffuse through 0.22 μm filters and influence the subpopulations of thymocytes.",

keywords = "Animals, CD4 Antigens, CD8 Antigens, Cell Differentiation/immunology, Cell Line, Transformed/immunology, Diffusion Chambers, Culture, Leukemia L1210/immunology, Lymphocyte Subsets/immunology, Mice, Thymus Gland/cytology",

author = "J. Kawiak and M. Kawalec and G. Hoser and B. Miks and T. Skorski and Z. Pojda and H. Skurzak",

year = "1991",

language = "English",

volume = "18",

pages = "185--192",

journal = "Thymus",

issn = "0165-6090",

publisher = "Kluwer Academic Publishers",

number = "3",

}

TY - JOUR

T1 - Changes of thymocyte subpopulations induced by activities diffusing from leukemia L1210 cells

AU - Kawiak, J.

AU - Kawalec, M.

AU - Hoser, G.

AU - Miks, B.

AU - Skorski, T.

AU - Pojda, Z.

AU - Skurzak, H.

PY - 1991

Y1 - 1991

N2 - Mice with intraperitoneally inoculated leukemia L1210 cells had a lower total number of thymocytes and a markedly reduced percentage of L3T4+Lyt2+ (CD4+ 8+) thymocytes, but increased subpopulations of L3T4+Lyt2-, L3T4-Lyt2+, L3T4-Lyt2-. The percentage of Thy 1.2+ thymocytes was unchanged as compared with control animals. A similar effect was observed with leukemia cells (106) enclosed in diffusion chambers and implanted i.p. It is suggested that leukemia L1210 cells produce some activities which diffuse through 0.22 μm filters and influence the subpopulations of thymocytes.

AB - Mice with intraperitoneally inoculated leukemia L1210 cells had a lower total number of thymocytes and a markedly reduced percentage of L3T4+Lyt2+ (CD4+ 8+) thymocytes, but increased subpopulations of L3T4+Lyt2-, L3T4-Lyt2+, L3T4-Lyt2-. The percentage of Thy 1.2+ thymocytes was unchanged as compared with control animals. A similar effect was observed with leukemia cells (106) enclosed in diffusion chambers and implanted i.p. It is suggested that leukemia L1210 cells produce some activities which diffuse through 0.22 μm filters and influence the subpopulations of thymocytes.

KW - Animals

KW - CD4 Antigens

KW - CD8 Antigens

KW - Cell Differentiation/immunology

KW - Cell Line, Transformed/immunology

KW - Diffusion Chambers, Culture

KW - Leukemia L1210/immunology

KW - Lymphocyte Subsets/immunology

KW - Mice

KW - Thymus Gland/cytology

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M3 - Article

C2 - 1785132

AN - SCOPUS:0025997580

SN - 0165-6090

VL - 18

SP - 185

EP - 192

JO - Thymus

JF - Thymus

IS - 3

ER -

Changes of thymocyte subpopulations induced by activities diffusing from leukemia L1210 cells

Abstract

Keywords

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