Centromere spreading in acute nonlymphocytic leukemia

JH Gallo, S. Misawa, Joseph R. Testa

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Centromere spreading (CS) was observed in bone marrow chromosomes from a patient with acute myeloblastic leukemia (AML), prior to therapy. The abnormality was found in a direct specimen, in a 24-hr culture, and in a culture treated with the methotrexate synchronization technique. A small hypodiploid clone, 45,XY,-19, was also observed. This case provides further evidence that CS can occur in acute nonlymphocytic leukemia (ANLL). The possible relationship between CS and hypodiploidy in this and other reported cases of ANLL is discussed.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume12
Issue number2
DOIs
StatePublished - Jun 1984

Keywords

  • Aged
  • Bone Marrow/drug effects
  • Cells, Cultured
  • Centromere/physiology
  • Chromosome Aberrations
  • Chromosome Disorders
  • Chromosomes/physiology
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute/genetics
  • Male
  • Methotrexate/toxicity

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