Cell interactions with three-dimensional matrices

Edna Cukierman, Roumen Pankov, Kenneth M. Yamada

Research output: Contribution to journalReview articlepeer-review

791 Scopus citations

Abstract

Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.

Original languageEnglish
Pages (from-to)633-640
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2002

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