Abstract
Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.
Original language | English |
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Pages (from-to) | 633-640 |
Number of pages | 8 |
Journal | Current Opinion in Cell Biology |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - Oct 1 2002 |