TY - JOUR
T1 - CDw50 and ICAM‐3
T2 - Two names for the same molecule
AU - Juan, Manel
AU - Vilella, Ramon
AU - Mila, Jordi
AU - Yagüe, Jordi
AU - Miralles, Agusti
AU - Campbell, Kerry S.
AU - Friedrich, R. Joachim
AU - Cambier, John
AU - Vives, Jordi
AU - De Fougerolles, Antonin R.
AU - Springer, Timothy A.
PY - 1993/7
Y1 - 1993/7
N2 - CDw50 differentiation antigen is a molecule broadly expressed on hematopoetic cells but not on other cells. Previous experiments showed that CDw50 monoclonal antibodies (mAb) inhibited primary mixed lymphocyte culture (MLC). To understand the function of CDw50 better, we purified it and obtained peptide sequence. At the same time, intercellular adhesion molecule (ICAM)‐3, the third Iigand of lymphocyte function‐associated molecule 1, was described by mAb and subsequent cDNA cloning. Immunochemical, functional, and protein sequencing studies show that ICAM‐3 and CDw50 are the same glycoprotein, a 120‐kDa surface molecule with presumably an important role in the immune responses.
AB - CDw50 differentiation antigen is a molecule broadly expressed on hematopoetic cells but not on other cells. Previous experiments showed that CDw50 monoclonal antibodies (mAb) inhibited primary mixed lymphocyte culture (MLC). To understand the function of CDw50 better, we purified it and obtained peptide sequence. At the same time, intercellular adhesion molecule (ICAM)‐3, the third Iigand of lymphocyte function‐associated molecule 1, was described by mAb and subsequent cDNA cloning. Immunochemical, functional, and protein sequencing studies show that ICAM‐3 and CDw50 are the same glycoprotein, a 120‐kDa surface molecule with presumably an important role in the immune responses.
KW - Amino Acid Sequence
KW - Antibodies, Monoclonal
KW - Antigens, CD/chemistry
KW - Antigens, Differentiation/chemistry
KW - Cell Adhesion Molecules/chemistry
KW - Cloning, Molecular
KW - Humans
KW - Molecular Sequence Data
KW - Peptides/chemistry
KW - Sequence Alignment
KW - Transfection
UR - https://www.scopus.com/pages/publications/0027213539
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1993LM70800016&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1002/eji.1830230717
DO - 10.1002/eji.1830230717
M3 - Article
C2 - 8325327
SN - 0014-2980
VL - 23
SP - 1508
EP - 1512
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 7
ER -