Catastrophic DNA replication in unscheduled tetraploid cells

Gwenola Manic; Lorenzo Galluzzi; Ilio Vitale

doi:10.1016/j.tig.2022.04.005

Catastrophic DNA replication in unscheduled tetraploid cells

Gwenola Manic
, Lorenzo Galluzzi
, Ilio Vitale

Italian Institute for Genomic Medicine
IRCCS Fondazione del Piemonte per l'Oncologia - Candiolo (TO)
Cornell University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G₁ phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

Original language	English
Pages (from-to)	787-788
Number of pages	2
Journal	Trends in Genetics
Volume	38
Issue number	8
DOIs	https://doi.org/10.1016/j.tig.2022.04.005
State	Published - Aug 2022
Externally published	Yes

Keywords

Aneuploidy
Cell Cycle Proteins/genetics
DNA Replication/genetics
Humans
Mitosis
S Phase
Tetraploidy

Access to Document

10.1016/j.tig.2022.04.005

Cite this

@article{15fcd5b5d2024d15b6b5a4c38a8dba7e,

title = "Catastrophic DNA replication in unscheduled tetraploid cells",

abstract = "Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.",

keywords = "Aneuploidy, Cell Cycle Proteins/genetics, DNA Replication/genetics, Humans, Mitosis, S Phase, Tetraploidy",

author = "Gwenola Manic and Lorenzo Galluzzi and Ilio Vitale",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = aug,

doi = "10.1016/j.tig.2022.04.005",

language = "English",

volume = "38",

pages = "787--788",

journal = "Trends in Genetics",

issn = "0168-9525",

publisher = "Elsevier Ltd.",

number = "8",

}

TY - JOUR

T1 - Catastrophic DNA replication in unscheduled tetraploid cells

AU - Manic, Gwenola

AU - Galluzzi, Lorenzo

AU - Vitale, Ilio

PY - 2022/8

Y1 - 2022/8

N2 - Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

AB - Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

KW - Aneuploidy

KW - Cell Cycle Proteins/genetics

KW - DNA Replication/genetics

KW - Humans

KW - Mitosis

KW - S Phase

KW - Tetraploidy

UR - https://www.scopus.com/pages/publications/85129849519

U2 - 10.1016/j.tig.2022.04.005

DO - 10.1016/j.tig.2022.04.005

M3 - Article

C2 - 35490031

AN - SCOPUS:85129849519

SN - 0168-9525

VL - 38

SP - 787

EP - 788

JO - Trends in Genetics

JF - Trends in Genetics

IS - 8

ER -

Catastrophic DNA replication in unscheduled tetraploid cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this