Catastrophic DNA replication in unscheduled tetraploid cells

Gwenola Manic; Lorenzo Galluzzi; Ilio Vitale

doi:10.1016/j.tig.2022.04.005

Catastrophic DNA replication in unscheduled tetraploid cells

Gwenola Manic, Lorenzo Galluzzi, Ilio Vitale

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G₁ phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

Original language	English
Pages (from-to)	787-788
Number of pages	2
Journal	Trends in Genetics
Volume	38
Issue number	8
DOIs	https://doi.org/10.1016/j.tig.2022.04.005
State	Published - Aug 2022
Externally published	Yes

Keywords

Aneuploidy
Cell Cycle Proteins/genetics
DNA Replication/genetics
Humans
Mitosis
S Phase
Tetraploidy

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10.1016/j.tig.2022.04.005

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title = "Catastrophic DNA replication in unscheduled tetraploid cells",

abstract = "Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.",

keywords = "Aneuploidy, Cell Cycle Proteins/genetics, DNA Replication/genetics, Humans, Mitosis, S Phase, Tetraploidy",

author = "Gwenola Manic and Lorenzo Galluzzi and Ilio Vitale",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

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language = "English",

volume = "38",

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AU - Manic, Gwenola

AU - Galluzzi, Lorenzo

AU - Vitale, Ilio

PY - 2022/8

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N2 - Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

AB - Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

KW - Aneuploidy

KW - Cell Cycle Proteins/genetics

KW - DNA Replication/genetics

KW - Humans

KW - Mitosis

KW - S Phase

KW - Tetraploidy

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DO - 10.1016/j.tig.2022.04.005

M3 - Article

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SP - 787

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JO - Trends in Genetics

JF - Trends in Genetics

IS - 8

ER -

Catastrophic DNA replication in unscheduled tetraploid cells

Abstract

Keywords

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