Ca2+ Fluxes and Cancer

Saverio Marchi; Carlotta Giorgi; Lorenzo Galluzzi; Paolo Pinton

doi:10.1016/j.molcel.2020.04.017

Ca²⁺ Fluxes and Cancer

Saverio Marchi, Carlotta Giorgi, Lorenzo Galluzzi, Paolo Pinton

Research output: Contribution to journal › Review article › peer-review

152 Scopus citations

Abstract

Ca²⁺ ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca²⁺ transporters and other Ca²⁺-binding proteins, however, Ca²⁺ signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca²⁺ fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca²⁺ signaling in malignant cells.

Original language	English
Pages (from-to)	1055-1069
Number of pages	15
Journal	Molecular Cell
Volume	78
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2020.04.017
State	Published - Jun 18 2020
Externally published	Yes

Keywords

IPR
MCU complex
mitochondrial permeability transition
ORAI
store-operated calcium entry
TRP channels

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.molcel.2020.04.017

Cite this

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title = "Ca2+ Fluxes and Cancer",

abstract = "Ca2+ ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca2+ transporters and other Ca2+-binding proteins, however, Ca2+ signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca2+ fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca2+ signaling in malignant cells.",

keywords = "IPR, MCU complex, mitochondrial permeability transition, ORAI, store-operated calcium entry, TRP channels",

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AU - Marchi, Saverio

AU - Giorgi, Carlotta

AU - Galluzzi, Lorenzo

AU - Pinton, Paolo

PY - 2020/6/18

Y1 - 2020/6/18

N2 - Ca2+ ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca2+ transporters and other Ca2+-binding proteins, however, Ca2+ signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca2+ fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca2+ signaling in malignant cells.

AB - Ca2+ ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca2+ transporters and other Ca2+-binding proteins, however, Ca2+ signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca2+ fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca2+ signaling in malignant cells.

KW - IPR

KW - MCU complex

KW - mitochondrial permeability transition

KW - ORAI

KW - store-operated calcium entry

KW - TRP channels

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DO - 10.1016/j.molcel.2020.04.017

M3 - Review article

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JO - Molecular Cell

JF - Molecular Cell

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