Abstract
Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 917-918 |
| Number of pages | 2 |
| Journal | Trends in Cell Biology |
| Volume | 30 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2020 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- CDK4/CDK6 inhibitors
- MDM2
- PIDD1
- double-stand DNA breaks
- ionizing radiation
- type I interferon
- Humans
- Proto-Oncogene Proteins c-mdm2/genetics
- Tumor Suppressor Protein p53/genetics
- Caspase 2/genetics
- DNA Breaks, Double-Stranded
- Neoplasms/genetics
- Cell Cycle Checkpoints
- DNA Damage
- Apoptosis
- Radiation, Ionizing
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