Caspase 2 and p53 Reunited in Tumor Control

Giulia Petroni; Ilio Vitale; Lorenzo Galluzzi

doi:10.1016/j.tcb.2020.09.001

Caspase 2 and p53 Reunited in Tumor Control

Giulia Petroni, Ilio Vitale, Lorenzo Galluzzi

Research output: Contribution to journal › Article › peer-review

Abstract

Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.

Original language	English
Pages (from-to)	917-918
Number of pages	2
Journal	Trends in Cell Biology
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.tcb.2020.09.001
State	Published - Dec 2020
Externally published	Yes

Keywords

CDK4/CDK6 inhibitors
MDM2
PIDD1
double-stand DNA breaks
ionizing radiation
type I interferon
Humans
Proto-Oncogene Proteins c-mdm2/genetics
Tumor Suppressor Protein p53/genetics
Caspase 2/genetics
DNA Breaks, Double-Stranded
Neoplasms/genetics
Cell Cycle Checkpoints
DNA Damage
Apoptosis
Radiation, Ionizing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2020.09.001

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title = "Caspase 2 and p53 Reunited in Tumor Control",

abstract = "Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.",

keywords = "CDK4/CDK6 inhibitors, MDM2, PIDD1, double-stand DNA breaks, ionizing radiation, type I interferon, Humans, Proto-Oncogene Proteins c-mdm2/genetics, Tumor Suppressor Protein p53/genetics, Caspase 2/genetics, DNA Breaks, Double-Stranded, Neoplasms/genetics, Cell Cycle Checkpoints, DNA Damage, Apoptosis, Radiation, Ionizing",

author = "Giulia Petroni and Ilio Vitale and Lorenzo Galluzzi",

year = "2020",

month = dec,

doi = "10.1016/j.tcb.2020.09.001",

language = "English",

volume = "30",

pages = "917--918",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Ltd.",

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T1 - Caspase 2 and p53 Reunited in Tumor Control

AU - Petroni, Giulia

AU - Vitale, Ilio

AU - Galluzzi, Lorenzo

PY - 2020/12

Y1 - 2020/12

N2 - Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.

AB - Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.

KW - CDK4/CDK6 inhibitors

KW - MDM2

KW - PIDD1

KW - double-stand DNA breaks

KW - ionizing radiation

KW - type I interferon

KW - Humans

KW - Proto-Oncogene Proteins c-mdm2/genetics

KW - Tumor Suppressor Protein p53/genetics

KW - Caspase 2/genetics

KW - DNA Breaks, Double-Stranded

KW - Neoplasms/genetics

KW - Cell Cycle Checkpoints

KW - DNA Damage

KW - Apoptosis

KW - Radiation, Ionizing

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U2 - 10.1016/j.tcb.2020.09.001

DO - 10.1016/j.tcb.2020.09.001

M3 - Article

C2 - 32921524

AN - SCOPUS:85090575513

SN - 0962-8924

VL - 30

SP - 917

EP - 918

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 12

ER -

Caspase 2 and p53 Reunited in Tumor Control

Abstract

Keywords

UN SDGs

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