TY - JOUR
T1 - CAS proteins in health and disease
T2 - An update
AU - Nikonova, Anna S.
AU - Gaponova, Anna V.
AU - Kudinov, Alexander E.
AU - Golemis, Erica A.
PY - 2014/6
Y1 - 2014/6
N2 - The CAS family of scaffolding proteins has increasingly attracted scrutiny as important for regulation of cancer-associated signaling. BCAR1 (also known as p130Cas), NEDD9 (HEF1, Cas-L), EFS (Sin), and CASS4 (HEPL) are regulated by and mediate cell attachment, growth factor, and chemokine signaling. Altered expression and activity of CAS proteins are now known to promote metastasis and drug resistance in cancer, influence normal development, and contribute to the pathogenesis of heart and pulmonary disease. In this article, we provide an update on recently published studies describing signals regulating and regulated by CAS proteins, and evidence for biological activity of CAS proteins in normal development, cancer, and other pathological conditions.
AB - The CAS family of scaffolding proteins has increasingly attracted scrutiny as important for regulation of cancer-associated signaling. BCAR1 (also known as p130Cas), NEDD9 (HEF1, Cas-L), EFS (Sin), and CASS4 (HEPL) are regulated by and mediate cell attachment, growth factor, and chemokine signaling. Altered expression and activity of CAS proteins are now known to promote metastasis and drug resistance in cancer, influence normal development, and contribute to the pathogenesis of heart and pulmonary disease. In this article, we provide an update on recently published studies describing signals regulating and regulated by CAS proteins, and evidence for biological activity of CAS proteins in normal development, cancer, and other pathological conditions.
KW - human molecular disease
KW - protein function
KW - signal transduction
UR - http://www.scopus.com/inward/record.url?scp=84904514271&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000339669300002&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1002/iub.1282
DO - 10.1002/iub.1282
M3 - Review article
C2 - 24962474
SN - 1521-6543
VL - 66
SP - 387
EP - 395
JO - IUBMB Life
JF - IUBMB Life
IS - 6
ER -
