TY - JOUR
T1 - Cart
T2 - A conserved antigen receptor transmembrane motif
AU - Campbell, Kerry S.
AU - Bäckström, B. Thomas
AU - Tiefenthaler, Georg
AU - Palmer, Ed
PY - 1994
Y1 - 1994
N2 - We have compared the transmembrane sequences of 72 vertebrate antigen receptor (mIg and TCR) polypeptides. This allowed us to identify a Conserved Antigen Receptor Transmembrane (CART) motif which is present in all antigen receptor transmembrane domains from species as far removed as cartilaginous fish. Most of the amino acids in the CAR T motif are polar or aromatic and may interact with other proteins in the lipid environment. In addition, modeling the antigen receptor transmembrane domain in an a helical conformation places the CART residues on one face of the α helix. Thus, the CAR T motif may encode a structural unit which plays a role in the assembly and/or the signaling properties of lymphocyte antigen receptors. We speculate on the potential role of the CART motifs in lymphocyte signaling.
AB - We have compared the transmembrane sequences of 72 vertebrate antigen receptor (mIg and TCR) polypeptides. This allowed us to identify a Conserved Antigen Receptor Transmembrane (CART) motif which is present in all antigen receptor transmembrane domains from species as far removed as cartilaginous fish. Most of the amino acids in the CAR T motif are polar or aromatic and may interact with other proteins in the lipid environment. In addition, modeling the antigen receptor transmembrane domain in an a helical conformation places the CART residues on one face of the α helix. Thus, the CAR T motif may encode a structural unit which plays a role in the assembly and/or the signaling properties of lymphocyte antigen receptors. We speculate on the potential role of the CART motifs in lymphocyte signaling.
KW - B cell antigen receptor (BCR)
KW - CART motif
KW - Membrane immunoglobulin
KW - T cell antigen receptor (TCR)
KW - Transmembrane domains
UR - https://www.scopus.com/pages/publications/0028685999
U2 - 10.1006/smim.1994.1049
DO - 10.1006/smim.1994.1049
M3 - Article
C2 - 7654996
AN - SCOPUS:0028685999
SN - 1044-5323
VL - 6
SP - 393
EP - 410
JO - Seminars in Immunology
JF - Seminars in Immunology
IS - 6
ER -