Cardiovascular Concerns, Cancer Treatment, and Biological and Chronological Aging in Cancer: JACC Family Series

Dina Ioffe, Sanjana C. Bhatia-Patel, Sakshi Gandhi, Eman A. Hamad, Efrat Dotan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cardiovascular disease (CVD) and cancer are leading causes of death globally, particularly among the rapidly growing population of older adults (OAs). CVD is a leading cause of mortality among cancer survivors, often accelerated by cancer treatments associated with short- or long-term cardiotoxicity. Moreover, there is a dynamic relationship among CVD, cancer, and aging, characterized by shared risk factors and biological hallmarks, that plays an important role in caring for OAs, optimizing treatment approaches, and developing preventive strategies. Assessment of geriatric domains (eg, functional status, comorbidities, cognition, polypharmacy, nutritional status, social support, psychological well-being) is critical to individualizing treatment of OAs with cancer. The authors discuss considerations in caring for an aging population with cancer, including methods for the assessment of OAs with CVD and/or cardiovascular risk factors planned for cancer therapy. Multidisciplinary care is critical in optimizing patient outcomes and maintaining quality of life in this growing vulnerable population.

Original languageEnglish
Pages (from-to)143-158
Number of pages16
JournalJacc: Cardiooncology
Volume6
Issue number2
DOIs
StatePublished - Apr 2024

Keywords

  • aging
  • cancer
  • cardio-oncology
  • cardiovascular disease
  • geriatric assessment
  • geriatric domains
  • geriatric oncology

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