Cancer stem cells and strategies for targeted drug delivery

Jin Cao; Shubhmita Bhatnagar; Jiawei Wang; Xueyong Qi; Swayam Prabha; Jayanth Panyam

doi:10.1007/s13346-020-00863-9

Cancer stem cells and strategies for targeted drug delivery

Jin Cao, Shubhmita Bhatnagar, Jiawei Wang, Xueyong Qi, Swayam Prabha, Jayanth Panyam

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis, and drug resistance, as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.

Original language	English
Pages (from-to)	1779-1805
Number of pages	27
Journal	Drug Delivery and Translational Research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1007/s13346-020-00863-9
State	Published - Oct 2021
Externally published	Yes

Keywords

Anti-tumor therapy
Cancer biology
Cancer stem cells (CSCs)
Drug delivery system
Drug-resistance
Neoplasms/pathology
Humans
Antineoplastic Agents
Tumor Microenvironment
Neoplastic Stem Cells/pathology
Molecular Targeted Therapy
Drug Delivery Systems

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13346-020-00863-9

Cite this

@article{028836708199495ca256a4dbd8906d94,

title = "Cancer stem cells and strategies for targeted drug delivery",

abstract = "Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis, and drug resistance, as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.",

keywords = "Anti-tumor therapy, Cancer biology, Cancer stem cells (CSCs), Drug delivery system, Drug-resistance, Neoplasms/pathology, Humans, Antineoplastic Agents, Tumor Microenvironment, Neoplastic Stem Cells/pathology, Molecular Targeted Therapy, Drug Delivery Systems",

author = "Jin Cao and Shubhmita Bhatnagar and Jiawei Wang and Xueyong Qi and Swayam Prabha and Jayanth Panyam",

note = "Publisher Copyright: {\textcopyright} 2020, Controlled Release Society.",

year = "2021",

month = oct,

doi = "10.1007/s13346-020-00863-9",

language = "English",

volume = "11",

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journal = "Drug Delivery and Translational Research",

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}

TY - JOUR

T1 - Cancer stem cells and strategies for targeted drug delivery

AU - Cao, Jin

AU - Bhatnagar, Shubhmita

AU - Wang, Jiawei

AU - Qi, Xueyong

AU - Prabha, Swayam

AU - Panyam, Jayanth

PY - 2021/10

Y1 - 2021/10

N2 - Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis, and drug resistance, as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.

AB - Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis, and drug resistance, as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.

KW - Anti-tumor therapy

KW - Cancer biology

KW - Cancer stem cells (CSCs)

KW - Drug delivery system

KW - Drug-resistance

KW - Neoplasms/pathology

KW - Humans

KW - Antineoplastic Agents

KW - Tumor Microenvironment

KW - Neoplastic Stem Cells/pathology

KW - Molecular Targeted Therapy

KW - Drug Delivery Systems

UR - http://www.scopus.com/inward/record.url?scp=85093972883&partnerID=8YFLogxK

U2 - 10.1007/s13346-020-00863-9

DO - 10.1007/s13346-020-00863-9

M3 - Review article

C2 - 33095384

AN - SCOPUS:85093972883

SN - 2190-393X

VL - 11

SP - 1779

EP - 1805

JO - Drug Delivery and Translational Research

JF - Drug Delivery and Translational Research

IS - 5

ER -

Cancer stem cells and strategies for targeted drug delivery

Abstract

Keywords

UN SDGs

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