Calreticulin surface presentation can promote quality control of hematopoietic stem cells

Lorenzo Galluzzi; Guido Kroemer

doi:10.1016/j.it.2022.10.008

Calreticulin surface presentation can promote quality control of hematopoietic stem cells

Lorenzo Galluzzi
, Guido Kroemer

Cornell University
Centre de Recherche des Cordeliers
Université Paris-Sud
Assistance publique – Hôpitaux de Paris

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.

Original language	English
Pages (from-to)	950-952
Number of pages	3
Journal	Trends in Immunology
Volume	43
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2022.10.008
State	Published - Dec 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Calreticulin/metabolism
Hematopoiesis
Hematopoietic Stem Cells
Mice
Zebrafish

Access to Document

10.1016/j.it.2022.10.008

Cite this

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title = "Calreticulin surface presentation can promote quality control of hematopoietic stem cells",

abstract = "Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.",

keywords = "Animals, Calreticulin/metabolism, Hematopoiesis, Hematopoietic Stem Cells, Mice, Zebrafish",

author = "Lorenzo Galluzzi and Guido Kroemer",

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year = "2022",

month = dec,

doi = "10.1016/j.it.2022.10.008",

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volume = "43",

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AU - Galluzzi, Lorenzo

AU - Kroemer, Guido

PY - 2022/12

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N2 - Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.

AB - Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.

KW - Animals

KW - Calreticulin/metabolism

KW - Hematopoiesis

KW - Hematopoietic Stem Cells

KW - Mice

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/85140373210

U2 - 10.1016/j.it.2022.10.008

DO - 10.1016/j.it.2022.10.008

M3 - Article

C2 - 36307308

AN - SCOPUS:85140373210

SN - 1471-4906

VL - 43

SP - 950

EP - 952

JO - Trends in Immunology

JF - Trends in Immunology

IS - 12

ER -

Calreticulin surface presentation can promote quality control of hematopoietic stem cells

Abstract

UN SDGs

Keywords

Access to Document

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