Calreticulin surface presentation can promote quality control of hematopoietic stem cells

Lorenzo Galluzzi, Guido Kroemer

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.

Original languageEnglish
Pages (from-to)950-952
Number of pages3
JournalTrends in Immunology
Volume43
Issue number12
DOIs
StatePublished - Dec 2022
Externally publishedYes

Keywords

  • Animals
  • Calreticulin/metabolism
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Mice
  • Zebrafish

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