Abstract
Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.
Original language | English |
---|---|
Pages (from-to) | 1014-1016 |
Number of pages | 3 |
Journal | Cancer Cell |
Volume | 41 |
Issue number | 6 |
DOIs | |
State | Published - Jun 12 2023 |
Externally published | Yes |
Keywords
- Calreticulin/genetics
- Humans
- Monitoring, Immunologic
- Mutation
- Myeloid Cells/metabolism
- Phagocytes