Calreticulin exposure orchestrates innate immunosurveillance

Emma Guilbaud, Guido Kroemer, Lorenzo Galluzzi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.

Original languageEnglish
Pages (from-to)1014-1016
Number of pages3
JournalCancer Cell
Volume41
Issue number6
DOIs
StatePublished - Jun 12 2023
Externally publishedYes

Keywords

  • Calreticulin/genetics
  • Humans
  • Monitoring, Immunologic
  • Mutation
  • Myeloid Cells/metabolism
  • Phagocytes

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