Abstract
Brca1 mouse models were first reported in the mid-1990′s shortly after cloning the human gene. Since then, many mouse models with a range of mutations have been generated, some mimic patient mutations, others are designed to probe specific protein domains and functions. In this review, we discuss early and recent studies using engineered Brca1 mouse alleles, and their implications for understanding Brca1 protein function in the context of DNA repair, tumorigenesis, and anti-cancer therapeutics.
| Original language | English |
|---|---|
| Article number | 168372 |
| Pages (from-to) | 168372 |
| Journal | Journal of Molecular Biology |
| Volume | 436 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2024 |
Keywords
- Brca1
- DNA repair
- homologous recombination
- mouse models
- Animals
- Neoplasms, Experimental/drug therapy
- Humans
- DNA Repair
- Mice
- Mutation
- BRCA1 Protein/genetics
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