Brca1 Mouse Models: Functional Insights and Therapeutic Opportunities

Wei Ting Yueh, David J. Glass, Neil Johnson

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Brca1 mouse models were first reported in the mid-1990′s shortly after cloning the human gene. Since then, many mouse models with a range of mutations have been generated, some mimic patient mutations, others are designed to probe specific protein domains and functions. In this review, we discuss early and recent studies using engineered Brca1 mouse alleles, and their implications for understanding Brca1 protein function in the context of DNA repair, tumorigenesis, and anti-cancer therapeutics.

Original languageEnglish
Article number168372
Pages (from-to)168372
JournalJournal of Molecular Biology
Issue number1
StatePublished - Jan 1 2024


  • Brca1
  • DNA repair
  • homologous recombination
  • mouse models
  • Animals
  • Neoplasms, Experimental/drug therapy
  • Humans
  • DNA Repair
  • Mice
  • Mutation
  • BRCA1 Protein/genetics


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