Branching out to gain control: how the pre-TCR is linked to multiple functions: How the pre-TCR is linked to multiple functions

A. M. Kruisbeek; M. C. Haks; M. Carleton; A. M. Michie; J. C. Zuniga-Pflucker; D. L. Wiest

doi:10.1016/S0167-5699(00)01744-8

Branching out to gain control: how the pre-TCR is linked to multiple functions: How the pre-TCR is linked to multiple functions

A. M. Kruisbeek, M. C. Haks, M. Carleton, A. M. Michie, J. C. Zuniga-Pflucker, D. L. Wiest

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.

Original language	English
Pages (from-to)	637-644
Number of pages	8
Journal	Immunology Today
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/S0167-5699(00)01744-8 https://doi.org/10.1016/s0167-5699(00)01744-8
State	Published - 2000

Keywords

Alleles
Apoptosis
Cell Differentiation
Cell Division
Cell Survival
Clonal Deletion
Gene Expression Regulation
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Lymphocyte Activation/physiology
Membrane Glycoproteins/chemistry
Models, Immunological
Phosphorylation
Protein Kinases/physiology
Protein Processing, Post-Translational
Protein Subunits
Receptors, Antigen, T-Cell, alpha-beta/chemistry
Signal Transduction
T-Lymphocyte Subsets/immunology
Transcription Factors/physiology

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title = "Branching out to gain control: how the pre-TCR is linked to multiple functions: How the pre-TCR is linked to multiple functions",

abstract = "How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.",

keywords = "Alleles, Apoptosis, Cell Differentiation, Cell Division, Cell Survival, Clonal Deletion, Gene Expression Regulation, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Humans, Lymphocyte Activation/physiology, Membrane Glycoproteins/chemistry, Models, Immunological, Phosphorylation, Protein Kinases/physiology, Protein Processing, Post-Translational, Protein Subunits, Receptors, Antigen, T-Cell, alpha-beta/chemistry, Signal Transduction, T-Lymphocyte Subsets/immunology, Transcription Factors/physiology",

author = "Kruisbeek, {A. M.} and Haks, {M. C.} and M. Carleton and Michie, {A. M.} and Zuniga-Pflucker, {J. C.} and Wiest, {D. L.}",

note = "Times Cited: 19 English Review 383AB IMMUNOL TODAY",

year = "2000",

doi = "10.1016/S0167-5699(00)01744-8",

language = "English",

volume = "21",

pages = "637--644",

journal = "Immunology Today",

issn = "0167-5699",

publisher = "Elsevier B.V.",

number = "12",

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TY - JOUR

T1 - Branching out to gain control: how the pre-TCR is linked to multiple functions

T2 - How the pre-TCR is linked to multiple functions

AU - Kruisbeek, A. M.

AU - Haks, M. C.

AU - Carleton, M.

AU - Michie, A. M.

AU - Zuniga-Pflucker, J. C.

AU - Wiest, D. L.

N1 - Times Cited: 19 English Review 383AB IMMUNOL TODAY

PY - 2000

Y1 - 2000

N2 - How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.

AB - How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.

KW - Alleles

KW - Apoptosis

KW - Cell Differentiation

KW - Cell Division

KW - Cell Survival

KW - Clonal Deletion

KW - Gene Expression Regulation

KW - Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

KW - Humans

KW - Lymphocyte Activation/physiology

KW - Membrane Glycoproteins/chemistry

KW - Models, Immunological

KW - Phosphorylation

KW - Protein Kinases/physiology

KW - Protein Processing, Post-Translational

KW - Protein Subunits

KW - Receptors, Antigen, T-Cell, alpha-beta/chemistry

KW - Signal Transduction

KW - T-Lymphocyte Subsets/immunology

KW - Transcription Factors/physiology

UR - https://pubmed.ncbi.nlm.nih.gov/11114425/

UR - http://www.scopus.com/inward/record.url?scp=0034509457&partnerID=8YFLogxK

U2 - 10.1016/S0167-5699(00)01744-8

DO - 10.1016/S0167-5699(00)01744-8

M3 - Article

C2 - 11114425

SN - 0167-5699

VL - 21

SP - 637

EP - 644

JO - Immunology Today

JF - Immunology Today

IS - 12

ER -

Branching out to gain control: how the pre-TCR is linked to multiple functions: How the pre-TCR is linked to multiple functions

Abstract

Keywords

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