Brachytherapy for cancer of the female urethra

Bizhan Micaily, Michael F. Dzeda, Curtis T. Miyamoto, Luther W. Brady

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Carcinoma of the female urethra is uncommon.The review of literature and our own experience indicates that early distal urethral cancers (squamous and adenocarcinoma) can be treated either with surgery (70-80% 5-year survival) or with radiotherapy (brachytherapy) with excellent results (75% 5-year survival). Early proximal or entire urethral cancers (squamous and adenocarcinoma), if treated surgically, will require exenterative procedures. Alternatively, these cancers can be treated with a combination of external beam and brachytherapy with or without chemotherapy with good results and preservation of organs. Surgery can be used for failures or persistent tumors. Advanced cancers require a multimodality approach, and a combination of radiation and chemotherapy appears to be the optimal way to treat these patients-with surgery to be used for biopsy-proven persistent tumors or recurrences.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalSeminars in Surgical Oncology
Volume13
Issue number3
DOIs
StatePublished - May 1997

Keywords

  • Adenocarcinoma/diagnosis
  • Antineoplastic Agents/therapeutic use
  • Brachytherapy/methods
  • Carcinoma, Squamous Cell/diagnosis
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Female
  • Humans
  • Prognosis
  • Radiation Dosage
  • Survival Rate
  • Urethral Neoplasms/diagnosis

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