Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

Alexander Y. Deneka; Jeffrey C. Liu; Camille C.R. Ragin

doi:10.1007/978-3-319-78762-6_20

Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

Alexander Y. Deneka, Jeffrey C. Liu, Camille C.R. Ragin

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Human papillomavirus (HPV) infection is now established as a major causative agent for development of the head and neck cancers. HPV-initiated tumors of the oropharynx have better survival rates than HPV-negative cancers, and this appears likely to be associated with differences in the biology underlying these two diseases. We will discuss the role of HPV-encoded proteins in host infection and carcinogenesis; will review the emerging biology of intratypic variants of HPV, with numerous variants possessing different potential for malignancy; and will suggest areas for the further study. Finally, we will highlight global trends in HPV-associated oropharyngeal head and neck cancer incidence and prevalence rates, with recent data showing a dramatic increase of infection worldwide and differing infection rates in developed and developing nations.

Original language	English
Title of host publication	Current Cancer Research
Publisher	Springer Nature
Pages	545-583
Number of pages	39
DOIs	https://doi.org/10.1007/978-3-319-78762-6_20
State	Published - 2018

Publication series

Name	Current Cancer Research
ISSN (Print)	2199-2584
ISSN (Electronic)	2199-2592

Keywords

Human papillomavirus
Incidence
Mortality
Oropharyngeal cancers
Variants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-319-78762-6_20

Cite this

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abstract = "Human papillomavirus (HPV) infection is now established as a major causative agent for development of the head and neck cancers. HPV-initiated tumors of the oropharynx have better survival rates than HPV-negative cancers, and this appears likely to be associated with differences in the biology underlying these two diseases. We will discuss the role of HPV-encoded proteins in host infection and carcinogenesis; will review the emerging biology of intratypic variants of HPV, with numerous variants possessing different potential for malignancy; and will suggest areas for the further study. Finally, we will highlight global trends in HPV-associated oropharyngeal head and neck cancer incidence and prevalence rates, with recent data showing a dramatic increase of infection worldwide and differing infection rates in developed and developing nations.",

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doi = "10.1007/978-3-319-78762-6_20",

language = "English",

series = "Current Cancer Research",

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AU - Liu, Jeffrey C.

AU - Ragin, Camille C.R.

PY - 2018

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N2 - Human papillomavirus (HPV) infection is now established as a major causative agent for development of the head and neck cancers. HPV-initiated tumors of the oropharynx have better survival rates than HPV-negative cancers, and this appears likely to be associated with differences in the biology underlying these two diseases. We will discuss the role of HPV-encoded proteins in host infection and carcinogenesis; will review the emerging biology of intratypic variants of HPV, with numerous variants possessing different potential for malignancy; and will suggest areas for the further study. Finally, we will highlight global trends in HPV-associated oropharyngeal head and neck cancer incidence and prevalence rates, with recent data showing a dramatic increase of infection worldwide and differing infection rates in developed and developing nations.

AB - Human papillomavirus (HPV) infection is now established as a major causative agent for development of the head and neck cancers. HPV-initiated tumors of the oropharynx have better survival rates than HPV-negative cancers, and this appears likely to be associated with differences in the biology underlying these two diseases. We will discuss the role of HPV-encoded proteins in host infection and carcinogenesis; will review the emerging biology of intratypic variants of HPV, with numerous variants possessing different potential for malignancy; and will suggest areas for the further study. Finally, we will highlight global trends in HPV-associated oropharyngeal head and neck cancer incidence and prevalence rates, with recent data showing a dramatic increase of infection worldwide and differing infection rates in developed and developing nations.

KW - Human papillomavirus

KW - Incidence

KW - Mortality

KW - Oropharyngeal cancers

KW - Variants

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BT - Current Cancer Research

PB - Springer Nature

ER -

Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

Abstract

Publication series

Keywords

UN SDGs

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