Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

Alexander Y. Deneka, Jeffrey C. Liu, Camille C.R. Ragin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Human papillomavirus (HPV) infection is now established as a major causative agent for development of the head and neck cancers. HPV-initiated tumors of the oropharynx have better survival rates than HPV-negative cancers, and this appears likely to be associated with differences in the biology underlying these two diseases. We will discuss the role of HPV-encoded proteins in host infection and carcinogenesis; will review the emerging biology of intratypic variants of HPV, with numerous variants possessing different potential for malignancy; and will suggest areas for the further study. Finally, we will highlight global trends in HPV-associated oropharyngeal head and neck cancer incidence and prevalence rates, with recent data showing a dramatic increase of infection worldwide and differing infection rates in developed and developing nations.

Original languageEnglish
Title of host publicationCurrent Cancer Research
PublisherSpringer Nature
Number of pages39
StatePublished - 2018

Publication series

NameCurrent Cancer Research
ISSN (Print)2199-2584
ISSN (Electronic)2199-2592


  • Human papillomavirus
  • Incidence
  • Mortality
  • Oropharyngeal cancers
  • Variants


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