Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure

Clementina Mesaros; Andrew J. Worth; Nathaniel W. Snyder; Melpo Christofidou-Solomidou; Anil Vachani; Steven M. Albelda; Ian A. Blair

doi:10.4155/bio.15.53

Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure

Clementina Mesaros, Andrew J. Worth, Nathaniel W. Snyder, Melpo Christofidou-Solomidou, Anil Vachani, Steven M. Albelda, Ian A. Blair

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.

Original language	English
Pages (from-to)	1157-1173
Number of pages	17
Journal	Bioanalysis
Volume	7
Issue number	9
DOIs	https://doi.org/10.4155/bio.15.53
State	Published - May 1 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4155/bio.15.53

Cite this

@article{772be33e677145fc9ff287492c22f701,

title = "Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure",

abstract = "Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.",

author = "Clementina Mesaros and Worth, {Andrew J.} and Snyder, {Nathaniel W.} and Melpo Christofidou-Solomidou and Anil Vachani and Albelda, {Steven M.} and Blair, {Ian A.}",

note = "Publisher Copyright: {\textcopyright} 2015 IA Blair.",

year = "2015",

month = may,

day = "1",

doi = "10.4155/bio.15.53",

language = "English",

volume = "7",

pages = "1157--1173",

journal = "Bioanalysis",

issn = "1757-6180",

publisher = "Taylor and Francis Ltd.",

number = "9",

}

TY - JOUR

T1 - Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure

AU - Mesaros, Clementina

AU - Worth, Andrew J.

AU - Snyder, Nathaniel W.

AU - Christofidou-Solomidou, Melpo

AU - Vachani, Anil

AU - Albelda, Steven M.

AU - Blair, Ian A.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.

AB - Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.

UR - http://www.scopus.com/inward/record.url?scp=84930591191&partnerID=8YFLogxK

U2 - 10.4155/bio.15.53

DO - 10.4155/bio.15.53

M3 - Review article

C2 - 26039812

AN - SCOPUS:84930591191

SN - 1757-6180

VL - 7

SP - 1157

EP - 1173

JO - Bioanalysis

JF - Bioanalysis

IS - 9

ER -

Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this