Beneficial effect of MDL 73404 in dextran sulfate-mediated murine colitis

S. N.S. Murthy, J. D. Fondacaro, N. S. Murthy, H. S. Cooper, Frank Bolkenius

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We show here that MDL 73404, a water soluble analog of alpha-tocopherol, provides protective and healing effects in dextran sulfate sodium-mediated colitis in mice. MDL 73404, showed significant dose response at all levels of the disease. The maximum effective dose was 10 mg/kg/day, p.o. and the ED50 dose was 1.75 mg/kg/day, p.o. (mean). Histology showed remarkable prevention or healing depending upon the protocol. In all protocols, MDL 73404 was significantly better than olsalazine (150 mg/kg/day, p.o.). MDL 73404 also inhibited PGE2, 6-keto-PGF1alpha, TXB2 and LTB4. These results suggest that MDL 73404 provides protective and healing effects in this model.

Original languageEnglish
Pages (from-to)C233-C234
JournalAgents and Actions
Volume41
Issue number2 Supplement
DOIs
StatePublished - Aug 1994

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