BCR-ABL1 kinase: Hunting an elusive target with new weapons

Tomasz Skorski

doi:10.1016/j.chembiol.2011.11.001

BCR-ABL1 kinase: Hunting an elusive target with new weapons

Tomasz Skorski

Temple University

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Tyrosine kinase inhibitors such as imatinib, dasatinib, and nilotinib interfere with ATP-binding pocket to inhibit BCR-ABL1 kinase. A recent report in Cell by Grebien et al. paves the way for a new approach to target BCR-ABL1 kinase by interfering with its SH2-kinase domain interface.

Original language	English
Pages (from-to)	1352-1353
Number of pages	2
Journal	Chemistry and Biology
Volume	18
Issue number	11
DOIs	https://doi.org/10.1016/j.chembiol.2011.11.001
State	Published - Nov 23 2011

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title = "BCR-ABL1 kinase: Hunting an elusive target with new weapons",

abstract = "Tyrosine kinase inhibitors such as imatinib, dasatinib, and nilotinib interfere with ATP-binding pocket to inhibit BCR-ABL1 kinase. A recent report in Cell by Grebien et al. paves the way for a new approach to target BCR-ABL1 kinase by interfering with its SH2-kinase domain interface.",

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AB - Tyrosine kinase inhibitors such as imatinib, dasatinib, and nilotinib interfere with ATP-binding pocket to inhibit BCR-ABL1 kinase. A recent report in Cell by Grebien et al. paves the way for a new approach to target BCR-ABL1 kinase by interfering with its SH2-kinase domain interface.

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JO - Chemistry and Biology

JF - Chemistry and Biology

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BCR-ABL1 kinase: Hunting an elusive target with new weapons

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