Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis

Ting Zhang; Siddharth Balachandran

doi:10.1083/JCB.201905047

Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis

Ting Zhang, Siddharth Balachandran

Fox Chase Cancer Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death.

Original language	English
Pages (from-to)	1773-1775
Number of pages	3
Journal	Journal of Cell Biology
Volume	218
Issue number	6
DOIs	https://doi.org/10.1083/JCB.201905047
State	Published - Jun 3 2019

Keywords

Apoptosis
Bombs
Humans
Listeria
Necrosis
Protein Kinases
Receptor-Interacting Protein Serine-Threonine Kinases

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10.1083/JCB.201905047

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title = "Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis",

abstract = "RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death.",

keywords = "Apoptosis, Bombs, Humans, Listeria, Necrosis, Protein Kinases, Receptor-Interacting Protein Serine-Threonine Kinases",

author = "Ting Zhang and Siddharth Balachandran",

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AU - Balachandran, Siddharth

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KW - Necrosis

KW - Protein Kinases

KW - Receptor-Interacting Protein Serine-Threonine Kinases

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Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis

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Keywords

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