Abstract
RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death.
Original language | English |
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Pages (from-to) | 1773-1775 |
Number of pages | 3 |
Journal | Journal of Cell Biology |
Volume | 218 |
Issue number | 6 |
DOIs | |
State | Published - Jun 3 2019 |
Keywords
- Apoptosis
- Bombs
- Humans
- Listeria
- Necrosis
- Protein Kinases
- Receptor-Interacting Protein Serine-Threonine Kinases