BAX and BAK dynamics control mitochondrial DNA release during apoptosis

Takahiro Yamazaki; Lorenzo Galluzzi

doi:10.1038/s41418-022-00985-2

BAX and BAK dynamics control mitochondrial DNA release during apoptosis

Takahiro Yamazaki
, Lorenzo Galluzzi

Cornell University

Research output: Contribution to journal › Comment/debate

58 Scopus citations

Abstract

BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA.

Original language	English
Pages (from-to)	1296-1298
Number of pages	3
Journal	Cell Death and Differentiation
Volume	29
Issue number	6
DOIs	https://doi.org/10.1038/s41418-022-00985-2
State	Published - Jun 2022
Externally published	Yes

Keywords

Apoptosis/genetics
DNA, Mitochondrial/genetics
Mitochondria/genetics
bcl-2 Homologous Antagonist-Killer Protein/genetics
bcl-2-Associated X Protein/genetics

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10.1038/s41418-022-00985-2

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title = "BAX and BAK dynamics control mitochondrial DNA release during apoptosis",

abstract = "BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA.",

keywords = "Apoptosis/genetics, DNA, Mitochondrial/genetics, Mitochondria/genetics, bcl-2 Homologous Antagonist-Killer Protein/genetics, bcl-2-Associated X Protein/genetics",

author = "Takahiro Yamazaki and Lorenzo Galluzzi",

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T1 - BAX and BAK dynamics control mitochondrial DNA release during apoptosis

AU - Yamazaki, Takahiro

AU - Galluzzi, Lorenzo

PY - 2022/6

Y1 - 2022/6

N2 - BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA.

AB - BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA.

KW - Apoptosis/genetics

KW - DNA, Mitochondrial/genetics

KW - Mitochondria/genetics

KW - bcl-2 Homologous Antagonist-Killer Protein/genetics

KW - bcl-2-Associated X Protein/genetics

UR - https://www.scopus.com/pages/publications/85127281171

U2 - 10.1038/s41418-022-00985-2

DO - 10.1038/s41418-022-00985-2

M3 - Comment/debate

C2 - 35347233

AN - SCOPUS:85127281171

SN - 1350-9047

VL - 29

SP - 1296

EP - 1298

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 6

ER -

BAX and BAK dynamics control mitochondrial DNA release during apoptosis

Abstract

Keywords

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