BAX and BAK at the Gates of Innate Immunity

Lorenzo Galluzzi; Claire Vanpouille-Box

doi:10.1016/j.tcb.2018.02.010

BAX and BAK at the Gates of Innate Immunity

Lorenzo Galluzzi, Claire Vanpouille-Box

Research output: Contribution to journal › Short survey › peer-review

25 Scopus citations

Abstract

Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.

Original language	English
Pages (from-to)	343-345
Number of pages	3
Journal	Trends in Cell Biology
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.tcb.2018.02.010
State	Published - May 2018
Externally published	Yes

Keywords

cytochrome c
mitochondrial outer membrane permeabilization
mtDNA
regulated cell death
STING
type I interferon

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10.1016/j.tcb.2018.02.010

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title = "BAX and BAK at the Gates of Innate Immunity",

abstract = "Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.",

keywords = "cytochrome c, mitochondrial outer membrane permeabilization, mtDNA, regulated cell death, STING, type I interferon",

author = "Lorenzo Galluzzi and Claire Vanpouille-Box",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

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AU - Galluzzi, Lorenzo

AU - Vanpouille-Box, Claire

PY - 2018/5

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AB - Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.

KW - cytochrome c

KW - mitochondrial outer membrane permeabilization

KW - mtDNA

KW - regulated cell death

KW - STING

KW - type I interferon

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U2 - 10.1016/j.tcb.2018.02.010

DO - 10.1016/j.tcb.2018.02.010

M3 - Short survey

C2 - 29555208

AN - SCOPUS:85043984520

SN - 0962-8924

VL - 28

SP - 343

EP - 345

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 5

ER -

BAX and BAK at the Gates of Innate Immunity

Abstract

Keywords

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