Basic principles of chemotherapy and other systemic therapies

Christina S. Chu; Stephen C. Rubin

doi:10.1016/B978-0-323-77684-4.00023-4

Basic principles of chemotherapy and other systemic therapies

Christina S. Chu, Stephen C. Rubin

Surgery

Fox Chase Cancer Center

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Systemic therapies are a crucial part of the armamentarium in the fight against cancer. Though the modern era of chemotherapy began in the 1940s with the use of estrogen to treat prostate cancer, today’s weapons include developments in cytotoxic drugs, targeted agents, and immunotherapies. Novel formulations, alternative dosing regimens, and varying schedules, sequences, combinations, and routes of administration have abounded. Fortunately, advances in supportive therapies have also evolved to help ameliorate gastrointestinal and hematologic toxicities of these treatments. A thorough understanding of the mechanisms of tumor growth, as well as therapeutic drug mechanism of action, efficacy, potential toxicity, and options for ameliorating those toxicities are essential to optimizing patient care.

Original language	English
Title of host publication	DiSaia and Creasman Clinical Gynecologic Oncology
Publisher	Elsevier
Pages	443-463
Number of pages	21
ISBN (Electronic)	9780323776844
ISBN (Print)	9780323776868
DOIs	https://doi.org/10.1016/B978-0-323-77684-4.00023-4
State	Published - Jan 1 2023

Keywords

Chemotherapy
gynecologic cancer
hormonal therapy
immunotherapy
systemic therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-323-77684-4.00023-4

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AU - Rubin, Stephen C.

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AB - Systemic therapies are a crucial part of the armamentarium in the fight against cancer. Though the modern era of chemotherapy began in the 1940s with the use of estrogen to treat prostate cancer, today’s weapons include developments in cytotoxic drugs, targeted agents, and immunotherapies. Novel formulations, alternative dosing regimens, and varying schedules, sequences, combinations, and routes of administration have abounded. Fortunately, advances in supportive therapies have also evolved to help ameliorate gastrointestinal and hematologic toxicities of these treatments. A thorough understanding of the mechanisms of tumor growth, as well as therapeutic drug mechanism of action, efficacy, potential toxicity, and options for ameliorating those toxicities are essential to optimizing patient care.

KW - Chemotherapy

KW - gynecologic cancer

KW - hormonal therapy

KW - immunotherapy

KW - systemic therapy

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M3 - Chapter

AN - SCOPUS:85152324108

SN - 9780323776868

SP - 443

EP - 463

BT - DiSaia and Creasman Clinical Gynecologic Oncology

PB - Elsevier

ER -

Basic principles of chemotherapy and other systemic therapies

Abstract

Keywords

UN SDGs

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