Badania in vitro nad niedokrwistościa towarzyszaca przewlekłym stanom zapalnym--wpływ interleukiny-6 na ludzka erytropoeze.

M. Z. Ratajczak; J. Ratajczak; T. Skorski

Badania in vitro nad niedokrwistościa towarzyszaca przewlekłym stanom zapalnym--wpływ interleukiny-6 na ludzka erytropoeze.

Translated title of the contribution: In vitro studies on anemia in chronic inflammatory disease: influence of interleukin-6 on human erythropoietin

M. Z. Ratajczak, J. Ratajczak, T. Skorski

Instytutu-Centrum Medycyny Doświadczalnej i Klinicznej PAN.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The influence of interleukin-6 (Il-6) on human erythropoietic progenitors growth in vitro was evaluated. It was found Il-6 causes approximately 35% inhibition of early BFU-E growth stimulated with erythropoietin, kit ligand and interleukin-3, Il-6 did not inhibit erythroid colony formation by late BFU-E and CFU-E progenitors. This data suggests the role Il-6 as one of inflammatory cytokines in pathogenesis of anemia of chronic disease acting inhibitory at early BFU-E erythroid progenitors level.

Translated title of the contribution	In vitro studies on anemia in chronic inflammatory disease: influence of interleukin-6 on human erythropoietin
Original language	Polish
Pages (from-to)	172-175
Number of pages	4
Journal	Polski Merkuriusz Lekarski
Volume	2
Issue number	9
State	Published - Jan 1997

Keywords

Anemia/complications
Chronic Disease
Erythroid Precursor Cells/cytology
Humans
Inflammation/complications
Interleukin-6/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Badania in vitro nad niedokrwisto{\'s}cia towarzyszaca przewlek{\l}ym stanom zapalnym--wp{\l}yw interleukiny-6 na ludzka erytropoeze.",

abstract = "The influence of interleukin-6 (Il-6) on human erythropoietic progenitors growth in vitro was evaluated. It was found Il-6 causes approximately 35% inhibition of early BFU-E growth stimulated with erythropoietin, kit ligand and interleukin-3, Il-6 did not inhibit erythroid colony formation by late BFU-E and CFU-E progenitors. This data suggests the role Il-6 as one of inflammatory cytokines in pathogenesis of anemia of chronic disease acting inhibitory at early BFU-E erythroid progenitors level.",

keywords = "Anemia/complications, Chronic Disease, Erythroid Precursor Cells/cytology, Humans, Inflammation/complications, Interleukin-6/metabolism",

author = "Ratajczak, {M. Z.} and J. Ratajczak and T. Skorski",

year = "1997",

month = jan,

language = "Polish",

volume = "2",

pages = "172--175",

journal = "Polski Merkuriusz Lekarski",

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AU - Ratajczak, M. Z.

AU - Ratajczak, J.

AU - Skorski, T.

PY - 1997/1

Y1 - 1997/1

N2 - The influence of interleukin-6 (Il-6) on human erythropoietic progenitors growth in vitro was evaluated. It was found Il-6 causes approximately 35% inhibition of early BFU-E growth stimulated with erythropoietin, kit ligand and interleukin-3, Il-6 did not inhibit erythroid colony formation by late BFU-E and CFU-E progenitors. This data suggests the role Il-6 as one of inflammatory cytokines in pathogenesis of anemia of chronic disease acting inhibitory at early BFU-E erythroid progenitors level.

AB - The influence of interleukin-6 (Il-6) on human erythropoietic progenitors growth in vitro was evaluated. It was found Il-6 causes approximately 35% inhibition of early BFU-E growth stimulated with erythropoietin, kit ligand and interleukin-3, Il-6 did not inhibit erythroid colony formation by late BFU-E and CFU-E progenitors. This data suggests the role Il-6 as one of inflammatory cytokines in pathogenesis of anemia of chronic disease acting inhibitory at early BFU-E erythroid progenitors level.

KW - Anemia/complications

KW - Chronic Disease

KW - Erythroid Precursor Cells/cytology

KW - Humans

KW - Inflammation/complications

KW - Interleukin-6/metabolism

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VL - 2

SP - 172

EP - 175

JO - Polski Merkuriusz Lekarski

JF - Polski Merkuriusz Lekarski

IS - 9

ER -

Badania in vitro nad niedokrwistościa towarzyszaca przewlekłym stanom zapalnym--wpływ interleukiny-6 na ludzka erytropoeze.

Abstract

Keywords

UN SDGs

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