Badania in vitro nad niedokrwistościa towarzyszaca przewlekłym stanom zapalnym. Wpływ remombinowanej interleukiny-1 beta na ludzka erytropoezee.

M. Z. Ratajczak; J. Ratajczak; W. I. Kuczyński; T. Skórski

Badania in vitro nad niedokrwistościa towarzyszaca przewlekłym stanom zapalnym. Wpływ remombinowanej interleukiny-1 beta na ludzka erytropoezee.

Translated title of the contribution: In-vitro study of anemia in chronic inflammatory conditions. Effect of recombined interleukin-1 beta on human erythropoiesis

M. Z. Ratajczak, J. Ratajczak, W. I. Kuczyński, T. Skórski

Zakładu Immunologii CSK WAM

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Study was inspired by the suggestion that interleukin 1-beta (IL-1 beta), one of the major inflammatory mediators, is directly responsible for anaemia of chronic inflammatory conditions. Effect of IL-beta was studied in vitro on methyl cellulose cultures of normal human bone marrow cells, the inoculate having been previously highly enriched in progenitor and stem cells. Our data did not support results reported by others that IL-1 beta is a strong inhibitor of early stages of erythropoiesis in vitro measured by early and late BFU-E formation. About 30% statistically not significant CFU-E inhibition was observed. Above studies show that IL-1 beta role in the development of anaemia associated with chronic inflammatory diseases requires further studies.

Translated title of the contribution	In-vitro study of anemia in chronic inflammatory conditions. Effect of recombined interleukin-1 beta on human erythropoiesis
Original language	Polish
Pages (from-to)	97-104
Number of pages	8
Journal	Polish Archives of Internal Medicine
Volume	91
Issue number	2
State	Published - Feb 1994

Keywords

Anemia/etiology
Bone Marrow
Cells, Cultured
Chronic Disease
Erythropoiesis/physiology
Humans
Inflammation/complications
Interleukin-1/physiology
Recombinant Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{9d07550606ed4ff88e7879e772f66563,

title = "Badania in vitro nad niedokrwisto{\'s}cia towarzyszaca przewlek{\l}ym stanom zapalnym. Wp{\l}yw remombinowanej interleukiny-1 beta na ludzka erytropoezee.",

abstract = "Study was inspired by the suggestion that interleukin 1-beta (IL-1 beta), one of the major inflammatory mediators, is directly responsible for anaemia of chronic inflammatory conditions. Effect of IL-beta was studied in vitro on methyl cellulose cultures of normal human bone marrow cells, the inoculate having been previously highly enriched in progenitor and stem cells. Our data did not support results reported by others that IL-1 beta is a strong inhibitor of early stages of erythropoiesis in vitro measured by early and late BFU-E formation. About 30% statistically not significant CFU-E inhibition was observed. Above studies show that IL-1 beta role in the development of anaemia associated with chronic inflammatory diseases requires further studies.",

keywords = "Anemia/etiology, Bone Marrow, Cells, Cultured, Chronic Disease, Erythropoiesis/physiology, Humans, Inflammation/complications, Interleukin-1/physiology, Recombinant Proteins",

author = "Ratajczak, {M. Z.} and J. Ratajczak and Kuczy{\'n}ski, {W. I.} and T. Sk{\'o}rski",

year = "1994",

month = feb,

language = "Polish",

volume = "91",

pages = "97--104",

journal = "Polish Archives of Internal Medicine",

issn = "0032-3772",

publisher = "Medycyna Praktyczna Cholerzyn",

number = "2",

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TY - JOUR

T1 - Badania in vitro nad niedokrwistościa towarzyszaca przewlekłym stanom zapalnym. Wpływ remombinowanej interleukiny-1 beta na ludzka erytropoezee.

AU - Ratajczak, M. Z.

AU - Ratajczak, J.

AU - Kuczyński, W. I.

AU - Skórski, T.

PY - 1994/2

Y1 - 1994/2

N2 - Study was inspired by the suggestion that interleukin 1-beta (IL-1 beta), one of the major inflammatory mediators, is directly responsible for anaemia of chronic inflammatory conditions. Effect of IL-beta was studied in vitro on methyl cellulose cultures of normal human bone marrow cells, the inoculate having been previously highly enriched in progenitor and stem cells. Our data did not support results reported by others that IL-1 beta is a strong inhibitor of early stages of erythropoiesis in vitro measured by early and late BFU-E formation. About 30% statistically not significant CFU-E inhibition was observed. Above studies show that IL-1 beta role in the development of anaemia associated with chronic inflammatory diseases requires further studies.

AB - Study was inspired by the suggestion that interleukin 1-beta (IL-1 beta), one of the major inflammatory mediators, is directly responsible for anaemia of chronic inflammatory conditions. Effect of IL-beta was studied in vitro on methyl cellulose cultures of normal human bone marrow cells, the inoculate having been previously highly enriched in progenitor and stem cells. Our data did not support results reported by others that IL-1 beta is a strong inhibitor of early stages of erythropoiesis in vitro measured by early and late BFU-E formation. About 30% statistically not significant CFU-E inhibition was observed. Above studies show that IL-1 beta role in the development of anaemia associated with chronic inflammatory diseases requires further studies.

KW - Anemia/etiology

KW - Bone Marrow

KW - Cells, Cultured

KW - Chronic Disease

KW - Erythropoiesis/physiology

KW - Humans

KW - Inflammation/complications

KW - Interleukin-1/physiology

KW - Recombinant Proteins

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M3 - Article

C2 - 8008622

AN - SCOPUS:0028380829

SN - 0032-3772

VL - 91

SP - 97

EP - 104

JO - Polish Archives of Internal Medicine

JF - Polish Archives of Internal Medicine

IS - 2

ER -

Badania in vitro nad niedokrwistościa towarzyszaca przewlekłym stanom zapalnym. Wpływ remombinowanej interleukiny-1 beta na ludzka erytropoezee.

Abstract

Keywords

UN SDGs

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