Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

Andreas Willerslev-Olsen; Thorbjørn Krejsgaard; Lise M. Lindahl; Charlotte Menne Bonefeld; Mariusz A. Wasik; Sergei B. Koralov; Carsten Geisler; Mogens Kilian; Lars Iversen; Anders Woetmann; Niels Odum

doi:10.3390/toxins5081402

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise M. Lindahl, Charlotte Menne Bonefeld, Mariusz A. Wasik, Sergei B. Koralov, Carsten Geisler, Mogens Kilian, Lars Iversen, Anders Woetmann, Niels Odum

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

Original language	English
Pages (from-to)	1402-1421
Number of pages	20
Journal	Toxins
Volume	5
Issue number	8
DOIs	https://doi.org/10.3390/toxins5081402
State	Published - Aug 2013
Externally published	Yes

Keywords

Cutaneous T-cell lymphoma
Enterotoxins
Infections
Superantigens
staphylococcus aureus

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10.3390/toxins5081402

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title = "Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma",

abstract = "In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.",

keywords = "Cutaneous T-cell lymphoma, Enterotoxins, Infections, Superantigens, staphylococcus aureus",

author = "Andreas Willerslev-Olsen and Thorbj{\o}rn Krejsgaard and Lindahl, {Lise M.} and Bonefeld, {Charlotte Menne} and Wasik, {Mariusz A.} and Koralov, {Sergei B.} and Carsten Geisler and Mogens Kilian and Lars Iversen and Anders Woetmann and Niels Odum",

year = "2013",

month = aug,

doi = "10.3390/toxins5081402",

language = "English",

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pages = "1402--1421",

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TY - JOUR

T1 - Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

AU - Willerslev-Olsen, Andreas

AU - Krejsgaard, Thorbjørn

AU - Lindahl, Lise M.

AU - Bonefeld, Charlotte Menne

AU - Wasik, Mariusz A.

AU - Koralov, Sergei B.

AU - Geisler, Carsten

AU - Kilian, Mogens

AU - Iversen, Lars

AU - Woetmann, Anders

AU - Odum, Niels

PY - 2013/8

Y1 - 2013/8

N2 - In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

AB - In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

KW - Cutaneous T-cell lymphoma

KW - Enterotoxins

KW - Infections

KW - Superantigens

KW - staphylococcus aureus

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U2 - 10.3390/toxins5081402

DO - 10.3390/toxins5081402

M3 - Review article

AN - SCOPUS:84882807228

SN - 2072-6651

VL - 5

SP - 1402

EP - 1421

JO - Toxins

JF - Toxins

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ER -

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

Abstract

Keywords

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