Bacterial antigens unleash tumor-targeting immunity

Nina Boeck; Zlatko Trajanoski; Lorenzo Galluzzi

doi:10.1016/j.chom.2023.11.001

Bacterial antigens unleash tumor-targeting immunity

Nina Boeck, Zlatko Trajanoski, Lorenzo Galluzzi

Research output: Contribution to journal › Article › peer-review

Abstract

The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.

Original language	English
Pages (from-to)	1945-1947
Number of pages	3
Journal	Cell Host and Microbe
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.chom.2023.11.001
State	Published - Dec 13 2023
Externally published	Yes

Keywords

Antigens, Bacterial
Colorectal Neoplasms/microbiology
Epitopes
Gastrointestinal Microbiome/physiology
Humans
Immunity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.chom.2023.11.001

Cite this

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title = "Bacterial antigens unleash tumor-targeting immunity",

abstract = "The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.",

keywords = "Antigens, Bacterial, Colorectal Neoplasms/microbiology, Epitopes, Gastrointestinal Microbiome/physiology, Humans, Immunity",

author = "Nina Boeck and Zlatko Trajanoski and Lorenzo Galluzzi",

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AU - Boeck, Nina

AU - Trajanoski, Zlatko

AU - Galluzzi, Lorenzo

PY - 2023/12/13

Y1 - 2023/12/13

N2 - The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.

AB - The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.

KW - Antigens, Bacterial

KW - Colorectal Neoplasms/microbiology

KW - Epitopes

KW - Gastrointestinal Microbiome/physiology

KW - Humans

KW - Immunity

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U2 - 10.1016/j.chom.2023.11.001

DO - 10.1016/j.chom.2023.11.001

M3 - Article

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AN - SCOPUS:85179479216

SN - 1931-3128

VL - 31

SP - 1945

EP - 1947

JO - Cell Host and Microbe

JF - Cell Host and Microbe

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ER -

Bacterial antigens unleash tumor-targeting immunity

Abstract

Keywords

UN SDGs

Access to Document

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