TY - JOUR
T1 - B Cell Lymphomas of the GI Tract
AU - Small, Sara
AU - Barnea Slonim, Liron
AU - Williams, Corinne
AU - Karmali, Reem
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/4/8
Y1 - 2021/4/8
N2 - PURPOSE OF THE REVIEW: Primary GI lymphomas of B cell origin are a diverse group of lymphomas. In this article, we provide an overview of the diagnosis, pathologic and molecular features, and management of these varied lymphomas.RECENT FINDINGS: The most common primary GI lymphomas are diffuse large B cell lymphoma (DLBCL) and marginal zone lymphomas (MZL), but follicular lymphomas (FL), mantle cell lymphomas (MCL), post-transplant lymphoproliferative disorders (PTLD), and Burkitt lymphoma of the GI tract also occur. Many features of these lymphomas are similar to their nodal counterparts, but certain clinical and biological aspects are unique. Diagnostic and treatment strategies for these lymphomas continue to evolve over time. There are ongoing discoveries about the unique pathophysiology, molecular characteristics, and complications of primary B cell GI lymphomas that are already leading to improvements in management of this histologically diverse set of lymphomas.
AB - PURPOSE OF THE REVIEW: Primary GI lymphomas of B cell origin are a diverse group of lymphomas. In this article, we provide an overview of the diagnosis, pathologic and molecular features, and management of these varied lymphomas.RECENT FINDINGS: The most common primary GI lymphomas are diffuse large B cell lymphoma (DLBCL) and marginal zone lymphomas (MZL), but follicular lymphomas (FL), mantle cell lymphomas (MCL), post-transplant lymphoproliferative disorders (PTLD), and Burkitt lymphoma of the GI tract also occur. Many features of these lymphomas are similar to their nodal counterparts, but certain clinical and biological aspects are unique. Diagnostic and treatment strategies for these lymphomas continue to evolve over time. There are ongoing discoveries about the unique pathophysiology, molecular characteristics, and complications of primary B cell GI lymphomas that are already leading to improvements in management of this histologically diverse set of lymphomas.
KW - Gastrointestinal Neoplasms/genetics
KW - Humans
KW - Lymphoma, B-Cell/diagnosis
KW - Lymphoma, Follicular/diagnosis
KW - Lymphoproliferative Disorders/diagnosis
UR - http://www.scopus.com/inward/record.url?scp=85105604596&partnerID=8YFLogxK
U2 - 10.1007/s11894-021-00811-8
DO - 10.1007/s11894-021-00811-8
M3 - Review article
C2 - 33963950
AN - SCOPUS:85105604596
SN - 1522-8037
VL - 23
JO - Current Gastroenterology Reports
JF - Current Gastroenterology Reports
IS - 7
M1 - 9
ER -